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Principaux documents

Y0000359

Acebutolol impurity B

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl}acetamide, Diacetolol

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About This Item

Formule empirique (notation de Hill):
C16H24N2O4
Numéro CAS:
Poids moléculaire :
308.37
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

acebutolol

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

InChI

1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)

Clé InChI

AWOGXJOBNAWQSF-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Separation of acebutolol and diacetolol diastereomers by reversed-phase high-performance liquid chromatography.
A A Gulaid et al.
Journal of chromatography, 318(2), 393-397 (1985-01-18)
Jun Shik Choi et al.
Archives of pharmacal research, 25(4), 541-545 (2002-09-07)
Pharmacokinetic characteristics of acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure. Plasma concentrations of acebutolol and diacetolol were determined by a high performance liquid chromatography assay.
High-performance liquid chromatographic determination of diacetolol enantiomers.
M Piquette-Miller et al.
Journal of chromatography, 533, 300-303 (1990-11-30)
M J Boutroy et al.
European journal of clinical pharmacology, 30(6), 737-739 (1986-01-01)
The concentrations of acebutolol and of its main active metabolite diacetolol in milk and plasma were studied in 7 hypertensive mothers treated with acebutolol, a cardioselective beta-adrenoceptor blocking agent. Clinical monitoring on their newborn babies was also done, as well
M Piquette-Miller et al.
Journal of pharmaceutical sciences, 80(4), 313-316 (1991-04-01)
The chiral beta-blocker acebutolol (AC) is marketed as a racemic mixture. Both AC and its major metabolite, diacetotol (DC), are chiral, the S-enantiomer possessing beta-blocking activity. The pharmacokinetics of AC and DC enantiomers was determined in 12 healthy subjects following

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