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Norchlordiazepoxide solution

1.0 mg/mL (Acetonitrile:DMSO (80:20)(v/v)), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C15H12ClN3O
Numéro CAS:
Poids moléculaire :
285.73
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Niveau de qualité

Forme

liquid

Caractéristiques

(Snap-N-Spike®)

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL (Acetonitrile:DMSO (80:20)(v/v))

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

ClC1=CC2=C(N=C(N)C[N+]([O-])=C2C3=CC=CC=C3)C=C1

InChI

1S/C15H12ClN3O/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)19(20)9-14(17)18-13/h1-8H,9H2,(H2,17,18)

Clé InChI

LNLMGKOHYYEWMY-UHFFFAOYSA-N

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Description générale

Norchlordiazepoxide is a major urinary metabolite of the benzodiazepine chlordiazepoxide, indicated for short term treatment of severe anxiety and for the management of acute alcohol withdrawal syndrome. The metabolite, also known as N-desmethylchlordiazepoxide, is pharmacologically active. This Certified Spiking Solution® is suitable for GC/MS or LC/MS methods in chlordiazepoxide testing for forensic analysis, urine drug testing, or clinical toxicology.

Application


  • Immunoassay detection of benzodiazepines: A study assessed the efficacy of immunoassays in detecting benzodiazepines and their metabolites in blood, including Norchlordiazepoxide. This research is vital for clinical toxicology and forensic applications, providing essential insights into drug monitoring and abuse detection (Huang & Moody, 1995).

  • High-performance liquid chromatographic method: A method for determining clonazepam and other benzodiazepines in serum was developed, applicable to Norchlordiazepoxide. This technique underscores the compound′s clinical relevance and enhances pharmacokinetic and therapeutic drug monitoring (Haver et al., 1986).

  • Photolytic derivatization for LCEC: Research highlighted the use of photolytic derivatization to improve the determinations of pharmaceuticals, including benzodiazepines like Norchlordiazepoxide, in biological fluids. This study contributes to the advancements in analytical chemistry, improving the accuracy of drug level assessments (Selavka et al., 1985).

  • Postmortem stability of benzodiazepines: An investigation into the postmortem stability of benzodiazepines in blood and tissues provided critical data for forensic sciences, particularly regarding the stability of compounds like Norchlordiazepoxide after death, aiding in legal and medical examinations (Levine et al., 1983).


Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

FlameExclamation mark

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

35.6 °F - closed cup

Point d'éclair (°C)

2.0 °C - closed cup


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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