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T4625

Sigma-Aldrich

Thiamine hydrochloride

reagent grade, ≥99% (HPLC)

Synonyme(s) :

Aneurine hydrochloride, Vitamin B1 hydrochloride

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About This Item

Formule empirique (notation de Hill):
C12H17ClN4OS · HCl
Numéro CAS:
67-03-8
Poids moléculaire :
337.27
Beilstein:
3851771
Numéro CE :
200-641-8
Numéro MDL:
MFCD00012780
Code UNSPSC :
12352209
eCl@ss :
34058006
ID de substance PubChem :
24900057
Nomenclature NACRES :
NA.26
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Source biologique

synthetic (organic)

Niveau de qualité

200

Qualité

reagent grade

Essai

≥99% (HPLC)

Forme

powder

Technique(s)

HPLC: suitable

Couleur

white

Pf

250 °C (dec.) (lit.)

Solubilité

H2O: 50 mg/mL, clear, colorless

Chaîne SMILES 

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

Clé InChI

DPJRMOMPQZCRJU-UHFFFAOYSA-M

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Catégories apparentées

Description générale

Thiamine is a water-soluble vitamin-B complex. Structurally, it possesses a five-membered thiazolium ring and a six-membered amino-pyrimidine ring connected by a methyl group. Thiamine is naturally available in fruits, vegetables, poultry, eggs.[1]

Application

Thiamine hydrochloride has been used as a vitamin supplement to the holidic medium[2] and in bacterial growth medium.[3][4]

Actions biochimiques/physiologiques

Thiamine is an essential coenzyme in carbohydrate metabolism.[5] Deficiency of thiamine causes beriberi, a neurological and cardiovascular disease.[1] Thiamine is administered in case of deficiency, either due to reduced intake or synthesis.[5][1] Congenital defect in the thiamine transporter gene SLC19A2 causes thiamine-responsive megaloblastic anemia syndrome (TRMA). Thiamine mimics acetylcholine in brain and possible exerts a role in Alzheimer′s disease.[1] Thiamine deficiency in ruminants causes polioencephalomalacia.[5]

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000425017
0000425017
0000405609
0000389288
0000379785

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Applied Pharmacology for Veterinary Technicians (2009)
Improved production of carotenes from synthetic medium by Blakeslea trispora in a bubble column reactor
Nanou K, et al.
Biochemical Engineering Journal, 67, 203-207 (2012)
A holidic medium for Drosophila melanogaster
Piper MDW, et al.
Nature Methods, 11(1), 100-100 (2013)
Clinical and biological aspects of thiamine deficiency
Vitamins in the prevention of human diseases (2011)
Real-time in vitro measurement of GTP hydrolysis
Shutes A and Der CJ
Methods, 37(2), 183-189 (2005)
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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