72340

Nicotinamide

≥99.5% (HPLC)

• Synonyme(s) : Acide nicotinique amide, Acide pyridine-3-carboxylique amide, Vitamine PP, Vitamine B₃
• Formule empirique (notation de Hill): C₆H₆N₂O
• Numéro CAS: 98-92-0
• Poids moléculaire : 122.12
• Numéro Beilstein : 383619
• Numéro CE : 202-713-4
• Numéro MDL: MFCD00006395
• Code UNSPSC : 12352205
• ID de substance PubChem : 57652413
• Nomenclature NACRES : NA.79

Propriétés

• Source biologique: synthetic
• Pureté: ≥99.5% (HPLC)
• Forme: powder or crystals
• Résidus de calcination: ≤0.2%
• Perte: ≤0.2% loss on drying, 20 °C (HV)
• Couleur: colorless to white
• Pf: 128-131 °C (lit.); 128-131 °C
• Traces d'anions: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤150 mg/kg
• Traces de cations: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• Application(s): cell analysis
• Chaîne SMILES: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• Clé InChI: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• Informations sur le gène: human ... PARP1(142) , SIRT2(22933)

Description

Description générale

Nicotinamide, a form of vitamin B3, is a building block of coenzymes NAD and NADP. Researchers consider it an important signaling molecule, and essential for cell metabolism studies. It has been used in multiple applications and research areas, namely cancer and viral research.

Application

Nicotinamide has been used:

• to study its effect on the expression of sirtuin 1
• in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay
• in cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to study its role in resveratrol (RSV)-stimulated hepatitis B virus replication

Actions biochimiques/physiologiques

Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

The coenzymes NAD and NADP take part in energy yielding metabolism and mediate several oxidation-reduction reactions. NAD hydrolyses to form nicotinamide, which is then transported to other tissues. Hydrolysis of nicotinamide yields nicotinic acid through salvage pathway.

Autres remarques

Coenzymes and Cofactors, vol. 2: Pyridine Nucleotide Coenzymes

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 302.0 °F - closed cup
• Point d'éclair (°C): 150 °C - closed cup
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves