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T1700000

Tolbutamide

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

1-Butyl-3-(4-methylphenylsulfonyl)urea, N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide

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About This Item

Formule empirique (notation de Hill):
C12H18N2O3S
Numéro CAS:
64-77-7
Poids moléculaire :
270.35
Numéro Beilstein :
1984428
Numéro MDL:
MFCD00027169
Code UNSPSC :
41116107
ID de substance PubChem :
329826684
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

tolbutamide

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1

InChI

1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

Clé InChI

JLRGJRBPOGGCBT-UHFFFAOYSA-N

Informations sur le gène

human ... ABCC8(6833) , KCNJ11(3767)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Tolbutamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Anti-diabetic agent. Metabolized by CYP2C9 (tolbutamide hydroxylase).

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Ning Wang et al.
ACS nano, 9(3), 3159-3168 (2015-03-12)
Cytochromes P450 (CYPs) enzymes are involved in catalyzing the metabolism of various endogenous and exogenous compounds. A rapid analysis of drug metabolism reactions by CYPs is required because they can metabolize 95% of current drugs in drug development and effective
Paulette B Goforth et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11405-11415 (2014-08-22)
The adipocyte-derived hormone leptin modulates neural systems appropriately for the status of body energy stores. Leptin inhibits lateral hypothalamic area (LHA) orexin (OX; also known as hypocretin)-producing neurons, which control feeding, activity, and energy expenditure, among other parameters. Our previous
Arian F Baquero et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 9982-9994 (2014-07-25)
Leptin is well known for its role in the regulation of energy homeostasis in adults, a mechanism that at least partially results from the inhibition of the activity of NPY/AgRP/GABA neurons (NAG) in the arcuate nucleus of the hypothalamus (ARH).
Cheng-Lung Hsu et al.
Oncotarget, 5(8), 2187-2197 (2014-04-20)
Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling.
Zhiping Lin et al.
Die Pharmazie, 69(7), 537-541 (2014-07-31)
To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo. Scutellarin and saline were intravenously administered to male Wistar rats via the caudal vein for 7 days consecutively. On the 8th
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