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Octanoyl-L-carnitine

analytical standard

Synonyme(s) :

(2R)-3-Carboxy-N,N,N-trimethyl-2-[(1-oxooctyl)oxy]-1-propanaminium inner salt, L-Carnitine octanoyl ester, C8-Carnitine

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About This Item

Formule empirique (notation de Hill):
C15H29NO4
Numéro CAS:
Poids moléculaire :
287.40
Numéro Beilstein :
5955761
Code UNSPSC :
41116107
Nomenclature NACRES :
NB.21

Qualité

analytical standard

Niveau de qualité

Pureté

≥97.0% (HPLC)

Activité optique

[α]/D -17±2°, c = 0.1 in H2O

Durée de conservation

limited shelf life, expiry date on the label

Impuretés

≤10% water

Application(s)

clinical testing

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

C[N+](C)(C)C[C@H](OC(CCCCCCC)=O)CC([O-])=O

InChI

1S/C15H29NO4/c1-5-6-7-8-9-10-15(19)20-13(11-14(17)18)12-16(2,3)4/h13H,5-12H2,1-4H3/t13-/m1/s1

Clé InChI

CXTATJFJDMJMIY-CYBMUJFWSA-N

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Description générale

Octanoyl-L-carnitine is a medium-chain endogenous ester of L-carnitine, obtained via acylcarnitine family transferase.

Application

Octanoyl-L-carnitine may be used as an analytical standard in the following:
  • Separation and identification of underivatized octanoyl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).
  • Quantification of the analyte in biological samples of patients treated with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS). The feasibility of adding L-carnitine to the peritoneal dialysis (PD) solution in APD-treated end-stage renal disease patients is investigated.

It may be used as a test material for investigating its rate of oxidation by mitochondria, isolated from the livers of fed, starved and glucagon treated virgin and lactating rats.

Produits recommandés

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria
Zammit AV
The Biochemical Journal, 190(2), 293-300 (1980)
L-Carnitine moiety assay: an up-to-date reappraisal covering the commonest methods for various applications
Marzo A and Curti S
Journal of Chromatography. B, Biomedical Sciences and Applications, 702(1-2), 1-20 (1997)
L-Carnitine status in end-stage renal disease patients on automated peritoneal dialysis
Liberato DL , et al.
Journal of Nephrology, 27(6), 699-706 (2014)
Minzhi Peng et al.
Journal of chromatography. A, 1319, 97-106 (2013-10-31)
A simple HPLC-MS/MS method has been established to separate and identify underivatized acylcarnitine isomers. Human plasma samples were deproteinized and concentrated. Acylcarnitines were separated on a reverse phase column and detected with triple quadrupole linear ion trap mass spectrometry. Deuterium-labeled

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