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05292

Sigma-Aldrich

Spermidine 0.1 M solution

Spermidine 0.1 M solution
1 of 1 reviewers received a sample product or took part in a promotion

Synonyme(s) :

Spermidine solution, Additive Screening Solution 30/Kit-No 78374

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About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.32
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Niveau de qualité

Densité

1.00 g/mL at 20 °C

Température de stockage

2-8°C

Chaîne SMILES 

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

Clé InChI

ATHGHQPFGPMSJY-UHFFFAOYSA-N

Informations sur le gène

mouse ... Odc1(18263)
rat ... Ppm1a(24666)

Actions biochimiques/physiologiques

Spermidine is a naturally occurring polyamine. It is associated with various cellular functions. It is responsible for the condensation and aggregation of DNA in aqueous solution.[1][2] Spermidine is known to extend lifespan via epigenetic modifications, induction of cell death and inhibition of necrosis.[3]
Spermidine 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Pictogrammes

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Faceshields, Gloves, Goggles


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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Induction of autophagy by spermidine promotes longevity.
Eisenberg T et al.
Nature Cell Biology, 11, 1305-1305 (2009)
Marjorie Catala et al.
Bio-protocol, 10(12), e3646-e3646 (2021-03-05)
Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional modifications during their biosynthesis. To fulfil their functions within cells, tRNAs undergo a tightly controlled biogenesis process leading to the formation of mature tRNAs. In addition, functions of tRNAs are often modulated
Satyanarayana U
Biochemistry (2014)
53rd National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) and National Meeting of Chemistry of Biological Systems ? Italian Chemical Society (SCI - Section CSB) (2008)
Maria Anna Bauer et al.
Cell cycle (Georgetown, Tex.), 12(2), 346-352 (2012-12-21)
Spermidine is a naturally occurring polyamine involved in multiple biological processes, including DNA metabolism, autophagy and aging. Like other polyamines, spermidine is also indispensable for successful reproduction at several stages. However, a direct influence on the actual fertilization process, i.e.

Questions

1–2 of 2 Questions  
  1. What is the pH of this spermidine solution please?

    1 answer
    1. The pH for this spermidine solution is not determined.

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  2. What is the solvent for this product? Is there an additive that allows it to remain stable at 4 degrees for an extended period of time?

    1 answer
    1. This product is a 0.1 M solution of spermidine in water. There is no preservative added. The material is sterile filtered and dispensed to autoclaved bottles. Thus microbial contamination is eliminated. Amines are oxidized by contact with air/oxygen. Stability will be maintained if the oxygen-free water is used for dilution and vial headspace is cleared of oxygen using an inert gas such as argon or nitrogen.

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Reviews

1 of 1 reviewers received a sample product or took part in a promotion

Active Filters

    • Review 1
    • Votes 0
    5 out of 5 stars.

    Dr.

    very good, my experiment got very good results_ thanks

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