This product is supplied as a neat or pure liquid with a density of 0.925 g/mL and a molecular weight of 145.25 g/mol. The minimum purity is 99%, thus the molarity will vary slightly from lot to lot. The molarity can range from 6.3 M ( 99%) to 6.4 M (100%). The lot-specific purity is reported on the Certificate of Analysis.
S2626
Spermidine
Spermidine
1 of 1 reviewers received a sample product or took part in a promotion
≥99% (GC)
Synonyme(s) :
1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
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About This Item
Formule linéaire :
NH2(CH2)3NH(CH2)4NH2
Numéro CAS:
Poids moléculaire :
145.25
Beilstein:
1698591
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.32
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Source biologique
synthetic
Essai
≥99% (GC)
Forme
solid or liquid (clear)
Impuretés
DNase, none detected
RNase, none detected
protease, none detected
Indice de réfraction
n20/D 1.479 (lit.)
Pf
22-25 °C
Solubilité
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
Densité
0.925 g/mL at 25 °C (lit.)
Température de stockage
room temp
Chaîne SMILES
NCCCCNCCCN
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
Clé InChI
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Informations sur le gène
rat ... Ppm1a(24666)
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Description générale
Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources.[1]
The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.[2]
Application
Actions biochimiques/physiologiques
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Attention
Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.
Autres remarques
Store under inert gas. Air sensitive; strongly hygroscopic.
Produit(s) apparenté(s)
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Eye Dam. 1 - Skin Corr. 1B
Code de la classe de stockage
8A - Combustible corrosive hazardous materials
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
233.6 °F - closed cup
Point d'éclair (°C)
112 °C - closed cup
Équipement de protection individuelle
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Les clients ont également consulté
Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
Parteek P, et al.
Frontiers in Chemistry, 11, 1164477-1164477 (2023)
In vitro Reconstitution Assay of miRNA Biogenesis by Arabidopsis DCL1.
Wang T
Bio-protocol, 5(8), e1454-e1454 (2015)
Quantitative Detection of Double-Stranded RNA-Mediated Gene Silencing of Parasitism Genes in Heterodera glycines.
Sukno SA
Journal of Nematology, 39(2), 145-152 (2007)
Evidence for the contribution of NOS1 gene polymorphism (rs3782206) to prefrontal function in schizophrenia patients and healthy controls.
Zhang Z
Neuropsychopharmacology, 40(6), 1383-1394 (2015)
Michi Miura et al.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 28(3-4), 381-393 (2020-10-19)
CUT&RUN is a powerful tool to study protein-DNA interactions in vivo. DNA fragments cleaved by the targeted micrococcal nuclease identify the footprints of DNA-binding proteins on the chromatin. We performed CUT&RUN on human lung carcinoma cell line A549 maintained in
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We have purchased S2626 spermidine 5 g. It does not say anywhere what molar concentration or if it is actually dissolved in water. Could you please inform me about that. I received 5 g i aprox 4 ml, and as I can read, the solubility is 50 mg /ml. ???
1 answer-
Helpful?
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Is the Molarity for all Spermidin batches the same ? Does the 6,4 M count also for xx-1G and xx-25G?
1 answer-
The molarity of this compound is the same for all pack sizes, but may vary slightly from lot to lot. The reported 6.4 M is assuming a 100% purity. The minimum purity specification is 99%.
Helpful?
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What is the molarity of Spermidine S2626-5G solution and what is the longterm storage condition?
1 answer-
This product is a neat or pure liquid. Based on a density of 0.925 g/mL and a molecular weight of 145.25, this material has an effective molarity of 6.4 M. It is recommended to store this solution as single-use aliquots at -20 ºC for no more than one month.
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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Is this a spermidine solution or a neat liquid, and what is the concentration?
1 answer-
Based on a density of 0.925 g/mL and a molecular weight of 145.25, this neat liquid has an effective molarity of 6.4 M.
Helpful?
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