393204

4-Hydroxynonenal

≥98% (HPLC), liquid, lipid peroxidation marker, Calbiochem^®

• Synonyme(s) : 4-Hydroxynonenal
• Formule empirique (notation de Hill): C₉H₁₆O₂
• Numéro CAS: 75899-68-2
• Poids moléculaire : 156.22
• Code UNSPSC : 12352114
• Nomenclature NACRES : NA.77

Propriétés

• product name: 4-Hydroxynonenal, 4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Solubilité: ethanol: 10 mg/mL
• Température de stockage: −70°C
• InChI: 1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
• Clé InChI: JVJFIQYAHPMBBX-FNORWQNLSA-N

Description

Description générale

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca²⁺ and irreversibly inhibits Na⁺, K⁺-ATPase activity (IC₅₀ = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).

A major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca²⁺. Irreversibly inhibits Na⁺-K⁺-ATPase activity (IC₅₀ = 120 µM).

Actions biochimiques/physiologiques

Primary Target
Na⁺, K⁺-ATPase activity

Product does not compete with ATP.

Target IC₅₀: 120 µM against Na⁺, K⁺-ATPase activity

Avertissement

Toxicity: Flammable (J)

Forme physique

Supplied at 10 mg/ml in ethanol

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Soh, Y., et al. 2000. Mol. Pharmacol.58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772.
Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135.
Siems, W.G., et al. 1996. Free Radic. Res.20, 215.
Ullrich, O., et al. 1996. Free Radic. Res.24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H319
• Conseils de prudence: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 57.2 °F - closed cup
• Point d'éclair (°C): 14 °C - closed cup