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870608H

Avanti

4-HNE-dimethylacetal

Avanti Research™ - A Croda Brand 870608H, hexane solution

Synonyme(s) :

(E)-4R-hydroxynonenal-dimethylacetal (Each vial contains 6.8mg which yields ~5.2mg 4-HNE after deprotection)

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About This Item

Formule empirique (notation de Hill):
C11H22O3
Numéro CAS:
119009-01-7
Poids moléculaire :
202.29
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

hexane solution

Conditionnement

pkg of 1 × 1 mL (870608H-5mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 870608H

Concentration

6.8 mg/mL (870608H-5mg)

Type de lipide

phosphoglycerides
bioactive lipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

CCCCC[C@@H](O)/C=C/C(OC)OC

Description générale

4-Hydroxynonenal (4-HNE or HNE) is an α,β-unsaturated hydroxyalkenal which is produced by lipid peroxidation in cells. 4-HNE has been hypothesized by several researchers to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.
The dimethylacetal derivative is a more stable form of 4-HNE which is good for long term storage of the compound during use. It can be easily converted to 4-HNE in the presence of acid.

Conditionnement

2 mL Amber Glass Sealed Ampule (870608H-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Mention d'avertissement

Danger

Classification des risques

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3

Organes cibles

Central nervous system, Nervous system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

-14.8 °F - closed cup

Point d'éclair (°C)

-26.0 °C - closed cup

Certificats d'analyse (COA)

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On the role of 4-hydroxynonenal in health and disease
Csala M, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(5), 826-838 (2015)
Kamelija Zarkovic
Molecular aspects of medicine, 24(4-5), 293-303 (2003-08-02)
The development of oxidative stress, in which production of highly reactive oxygen species (ROS) overwhelms antioxidant defenses, is a feature of many neurological diseases: ischemic, inflammatory, metabolic and degenerative. Oxidative stress is increasingly implicated in a number of neurodegenerative disorders
N Zarković et al.
Life sciences, 65(18-19), 1901-1904 (1999-11-27)
Immunohistochemical analysis of the distribution of the lipid peroxidation product 4-hydroxynonenal (HNE) in the brain of baboons exposed to experimental hemorrhagic traumatic shock or sepsis showed that systemic oxidative stress and the thereby generated HNE affect the blood:brain barrier and
Neven Zarkovic
Molecular aspects of medicine, 24(4-5), 281-291 (2003-08-02)
The review is focused on the currently major aspect of 4-hydroxynonenal (HNE) research--studies that combine biological activities of the aldehyde together with the methods of its identification in cells and tissues. Because there were some excellent reviews on HNE published
Yogesh C Awasthi et al.
Free radical biology & medicine, 37(5), 607-619 (2004-08-04)
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. Glutathione S-transferases (GSTs) can modulate
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