Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

Voir toute la documentation

930431

Sigma-Aldrich

SuTEx1-alkyne

≥95%

Synonyme(s) :

N-2-propyn-1-yl-4-(1H-1,2,4-triazol-1-ylsulfonyl)-benzamide

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C12H10N4O3S
Numéro CAS:
2509567-79-5
Poids moléculaire :
290.30
Numéro MDL:
MFCD34704578
Code UNSPSC :
12352101
Nomenclature NACRES :
NA.21

Description

Application: Chemoproteomics

Niveau de qualité

100

Essai

≥95%

Forme

powder

Pf

155 °C

Température de stockage

−20°C

Chaîne SMILES 

O=C(C1=CC=C(S(N2N=C([H])N=C2)(=O)=O)C=C1)NCC#C

Clé InChI

ZBNCPAXYEUCPRL-UHFFFAOYSA-N

Application

SuTEx1-alkyne is a probe that uses sulfur-triazole exchange chemistry to label tyrosines. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications (Zanon et al. 2021). The method uses light or heavy labelling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016)

Autres remarques

Profiling the proteome-wide selectivity of diverse electrophiles

A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile

Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

930423

CP-alkyne, ≥95%

930466

HMP-alkyne, ≥95%

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

Si vous avez besoin d'assistance, veuillez contacter Service Clients

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Profiling the proteome-wide selectivity of diverse electrophiles
Patrick R. A. Zanon ,Fengchao Yu, et al
ChemRxiv : the preprint server for chemistry (2021)
Rui Sun et al.
Chemical research in toxicology, 30(10), 1797-1803 (2017-09-30)
Reactive metabolites (RM) formed from bioactivation of drugs can covalently modify liver proteins and cause mechanism-based inactivation of major cytochrome P450 (CYP450) enzymes. Risk of bioactivation of a test compound is routinely examined as part of lead optimization efforts in
Yide He et al.
Talanta, 134, 468-475 (2015-01-27)
In this work, we present a two-step labeling approach for the efficient tagging with lanthanide-containing complexes. For this purpose, derivatization of the cysteine residues with an alkyne group acting as linker was done before the DOTA complex was introduced using
Ping Yu et al.
Nucleosides, nucleotides & nucleic acids, 40(7), 754-766 (2021-06-29)
We report herein comprehensive investigations of alkylation/sulfur exchange reactions of sulfur-containing substrates including nucleosides such as s2U, m5s2U, s4U, s2A and s2T-incorporated DNA enable by comprehensive screenings of the reagents (2a-2h). It has been proven that iodoacetamide (2a) displays the
Romain Tessier et al.
Angewandte Chemie (International ed. in English), 59(27), 10961-10970 (2020-04-02)
Current approaches to introduce terminal alkynes for bioorthogonal reactions into biomolecules still present limitations in terms of either reactivity, selectivity, or adduct stability. We present a method for the ethynylation of cysteine residues based on the use of ethynylbenziodoxolone (EBX)
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique