900864

4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

• Synonyme(s) : Bromo sulfonyl fluoride TMS-alkyne, Probe building block
• Formule empirique (notation de Hill): C₁₂H₁₄BrFO₂SSi
• Numéro CAS: 2088828-99-1
• Poids moléculaire : 349.29
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder or crystals
• Disponibilité: available only in USA
• Température de stockage: −20°C
• Chaîne SMILES: O=S(C(C(C#C[Si](C)(C)C)=C1)=CC=C1CBr)(F)=O

Description

Application

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Autres remarques

• 1.Technology Spotlight: Trifunctional Probe Building Blocks
• 2.Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Informations sur la sécurité

• Pictogrammes: GHS02
• Mention d'avertissement: Danger
• Mentions de danger: H242
• Conseils de prudence: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classification des risques: Self-react. C
• Code de la classe de stockage: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable