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Merck

Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy.

Proceedings of the National Academy of Sciences of the United States of America (2009-03-27)
Kyle E Broaders, Joel A Cohen, Tristan T Beaudette, Eric M Bachelder, Jean M J Fréchet
PMID19321415
RESUMEN

Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that are tunable over 2 orders of magnitude depending on the degree and type of acetal modification. Varying the degradation rate produces particles that perform better than poly(lactic-co-glycolic acid) and iron oxide, two commonly studied materials used for particulate immunotherapy, in major histocompatibility complex class I (MHC I) and MHC II presentation assays. Modulating the material properties leads to antigen presentation on MHC I via pathways that are dependent or independent of the transporter associated with antigen processing. To the best of our knowledge, this is the only example of a material that can be tuned to operate on different immunological pathways while maximizing immunological presentation.

MATERIALES
Referencia del producto
Marca
Descripción del producto
719897
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