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Merck

SAE0062

Sigma-Aldrich

Lipodisq®

Styrene:Maleic Anhydride Copolymer 2:1, Pre-hydrolyzed

Sinónimos:

Lipodisq Reagent, Lipodisq Solution

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.25

Quality Level

Storage temp.

room temp

General description

Lipodisq nanoparticles are usually made up of styrene maleic acid (SMA) copolymer and phospholipids. It has almost similar structure to that of nanodiscs. Lipodisq nanoparticles are considered as a good membrane mimetic system for the structural studies of membrane proteins.

Application

Lipodisq reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents.

Functional pH range: 5.5 - 8.0

Biochem/physiol Actions

Lipodisq nanoparticles are considered as a good membrane mimetic system for the structural studies of membrane proteins.

Packaging

100, 500 mg in poly bottle

Legal Information

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Characterization of the structure of lipodisq nanoparticles in the presence of KCNE1 by dynamic light scattering and transmission electron microscopy
Zhang R, et al.
Chemistry and Physics of Lipids, 203, 19-23 (2017)
Characterization of KCNE1 inside lipodisq nanoparticles for EPR spectroscopic studies of membrane proteins
Sahu I D, et al.
The Journal of Physical Chemistry B, 121(21), 5312-5321 (2017)
Lina Zhu et al.
PeerJ, 10, e13381-e13381 (2022-05-10)
Smoothened (SMO) protein is a member of the G protein-coupled receptor (GPCR) family that is involved in the Hedgehog (Hh) signaling pathway. It is a putative target for treating various cancers, including medulloblastoma and basal cell carcinoma (BCC). Characterizing membrane
Juan Francisco Bada Juarez et al.
Biochimica et biophysica acta. Biomembranes, 1862(3), 183152-183152 (2019-12-18)
Dopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in the central nervous system (CNS). These receptors mediate physiological functions ranging from voluntary movement and reward recognition to hormonal regulation and hypertension. Drugs targeting dopaminergic neurotransmission have been
Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8

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