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L8920

Sigma-Aldrich

Lipodisq®

Styrene:Maleic Anhydride Copolymer 2:1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.25

biological source

synthetic

Quality Level

200

form

powder

storage temp.

room temp

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Application

Lipodisq® has been used in nanoparticle preparation along with palmitoyloleoylphosphatidylcholine (POPC) and palmitoyloleoyl phosphatidylglycerol (POPG).
Lipodisq® reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. In general, Lipodisq polymers are potentially useful in mitigating the use of detergents for the solubilization of membrane proteins. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

Biochem/physiol Actions

Lipodisq® is detergent-free and is useful in membrane protein biophysical studies including electron microscopy (EM), circular dichroism (CD), electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) techniques as well as delivery vehicle.

Legal Information

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

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Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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13 Giant vesicles: A biomimetic tool for assessing membrane material properties and interactions
Characterization and Chemical Modification of the Silica Surface, 415-415 (2019)
Detergent-Free Formation and Physicochemical Characterization of Nanosized Lipid-Polymer Complexes: Lipodisq
Orwick MC, et al.
Angewandte Chemie (International ed. in English), 51(19), 4653-4657 (2012)
Juan Francisco Bada Juarez et al.
Biochimica et biophysica acta. Biomembranes, 1862(3), 183152-183152 (2019-12-18)
Dopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in the central nervous system (CNS). These receptors mediate physiological functions ranging from voluntary movement and reward recognition to hormonal regulation and hypertension. Drugs targeting dopaminergic neurotransmission have been
Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8

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