SAB4502958
Anti-TGF β Receptor I antibody produced in rabbit
affinity isolated antibody
Sinónimos:
ADRB2, ALK-5, Activin receptor-like kinase 5, ESK2, SKR4
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen 55 kDa
reactividad de especies
mouse, human, rat
concentración
~1 mg/mL
técnicas
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... TGFBR1(7046)
Categorías relacionadas
Descripción general
Anti-TGF β Receptor I Antibody detects endogenous levels of total TGF β Receptor I protein.
Transforming growth factor β receptor-1 (TGF-β R1), also known as activin receptor-like kinase 5 (ALK5) receptor, is encoded by the gene mapped to human chromosome 9q22.3. It is widely expressed in human tissues.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human TGF beta Receptor I.
Immunogen Range: 131-180
Immunogen Range: 131-180
Aplicación
Anti-TGF β Receptor I antibody produced in rabbit has been used for:
- Immunohistochemistry
- Western blotting
- Immunofluroscence
Acciones bioquímicas o fisiológicas
Transforming growth factor β receptor-1 (TGF-β R1) plays an essential role in carbon nanotube-induced fibrogenesis by enhancing collagen production in lung fibroblasts. TβR-dependent signals plays a crucial role in cell growth and differentiation, and polymorphism or mutation of TGF-β R1 leads to head and neck cancer. Activin receptor-like kinase 5 (ALK5) or TGF-β R1 promotes the phosphorylation of small mothers against decapentaplegic (Smad) 2 and Smad3. Activated ALK5 inhibits migration and proliferation of endothelial cells (ECs). ALK1 acts as an antagonist for ALK5/Smad signaling. Mutation of TGF-β R1 can also cause autosomal dominant skin cancer called multiple self-healing squamous epithelioma (MSSE) or Ferguson-Smith disease (FSD).
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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