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S1141

Sigma-Aldrich

Spermine tetrahydrochloride

BioReagent, for molecular biology

Sinónimos:

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C10H26N4 · 4HCl
Número de CAS:
306-67-2
Peso molecular:
348.18
Beilstein/REAXYS Number:
3911771
EC Number:
206-189-8
MDL number:
MFCD00012914
UNSPSC Code:
12352116
PubChem Substance ID:
24899462
NACRES:
NA.52

grade

for molecular biology

Quality Level

300

product line

BioReagent

form

solid

mp

310-311 °C (dec.) (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless to light yellow

foreign activity

DNase, RNase, protease, NICKase, none detected

storage temp.

room temp

SMILES string

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

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General description

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

related product

Referencia del producto
Descripción
Precios

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

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ODQ A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM).

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ODQ

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Sigma-Aldrich

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L L Vindeløv et al.
Cancer research, 40(11), 4295-4300 (1980-11-01)
Flow-cytometric DNA analysis yields information on ploidy and proliferative characteristics of a cell population. The analysis was implemented on small-cell anaplastic carcinoma of the lung using a rapid detergent technique for the preparation of fine-needle aspirates for DNA determination and
Binh V Vu et al.
PloS one, 7(12), e51863-e51863 (2013-01-04)
While most nucleic acids are intracellular, trace amounts of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), including micro RNAs, can also be found in peripheral blood. Many studies have suggested the potential utility of these circulating nucleic acids in prenatal
D M Hougaard et al.
The Biochemical journal, 238(1), 43-47 (1986-08-15)
Two recently developed fluorescence cytochemical methods, specific for spermidine and spermine, were used to localize polyamines in the endocrine pancreas. The polyamines were restricted to the insulin-producing beta-cells and were mainly associated with the secretory granules. Chemical polyamine determinations carried
D C Allison et al.
Annals of surgery, 214(6), 648-656 (1991-12-01)
The DNA content of 47 adenocarcinomas arising in the head of the pancreas from patients who had undergone successful pancreatoduodenectomy was measured. The DNA measurements of each tumor were made without knowledge of the clinical course by absorption cytometry performed
Davis, L., et al.
Basic Methods in Molecular Biology, 120-120 (1986)
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Protocolos

Spermine Tetrahydrochloride for Molecular Biology

This product is suitable for DNA precipitation from low salt aqueous buffers. It has been tested for the absence of proteases and nucleases.

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