495320

ODQ

≥98% (TLC and HPLC), nitric oxide (NO)-sensitive guanylyl cyclase inhibitor, powder

• Sinónimos: ODQ, 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
• Fórmula empírica (notación de Hill): C₉H₅N₃O₂
• Número CAS: 41443-28-1
• Peso molecular: 187.15
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00792620
• Assay: ≥98% (TLC and HPLC)
• Form: powder
• Storage condition: OK to freeze, protect from light

Propiedades

• Nombre del producto: ODQ, A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM).
• Quality Segment: 100
• assay: ≥98% (TLC and HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: light yellow
• solubility: DMSO: 25 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [n]21c(n[o][c]2=O)cnc3c1cccc3
• InChI: 1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
• InChI key: LZMHWZHOZLVYDL-UHFFFAOYSA-N

Descripción

General description

A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.

A potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ fails to inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
(NO)-sensitive guanylyl cyclase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 20 nM against nitric oxide (NO)-sensitive guanylyl cyclase

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527.
Brunner, F., et al. 1995. FEBS Lett.376, 262.
Garthwaite, J., et al. 1995. Mol. Pharmacol.48, 184.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable