The solubility specification was tested at 100 mg/ml in 1 M NaOH (refer to the specification sheet). Probenecid is soluble in chloroform, in dilute solutions of sodium hydroxide, then buffered to pH 7.4, and is nearly insoluble in water. It is also soluble in 1 M NaOH (50 mg/ml), producing a clear, colorless solution.
P8761
Probenecid
≥98% (NaOH, titration), powder, uricosuric agent
Sinónimos:
p-(Dipropylsulfamoyl)benzoic acid
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
25 g | Comprobar disponibilidad del carrito | $189.000 |
100 g | Comprobar disponibilidad del carrito | $311.000 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C13H19NO4S
Número CAS:
Peso molecular:
285.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
200-344-3
MDL number:
Assay:
≥98% (NaOH, titration)
Servicio técnico
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Permítanos ayudarleNombre del producto
Probenecid,
assay
≥98% (NaOH, titration)
Quality Segment
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
InChI
1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
InChI key
DBABZHXKTCFAPX-UHFFFAOYSA-N
Gene Information
human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376)
Application
Useful as an inhibitor of the organic anion transporter, MRP.
Probenecid has been used:
- as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assay
- as a component of calcium sensitive dye for calcium mobilization Studies
- as a supplement in Hank′s balanced salt solution (HBSS) assay buffer
Biochem/physiol Actions
Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Este artículo | |||
|---|---|---|---|
| description - | description United States Pharmacopeia (USP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard | description - |
| assay ≥98% (NaOH, titration) | assay - | assay - | assay - |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 300 |
| originator Merck & Co., Inc., Kenilworth, NJ, U.S. | originator - | originator - | originator - |
| Gene Information human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376) | Gene Information human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376) | Gene Information human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376) | Gene Information - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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