P0778

Pindolol

≥98% (TLC), β1-adrenoceptor antagonist, powder

• Sinónimos: 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
• Fórmula empírica (notación de Hill): C₁₄H₂₀N₂O₂
• Número CAS: 13523-86-9
• Peso molecular: 248.32
• NACRES: NA.77
• PubChem Substance ID: 24277795
• UNSPSC Code: 12352200
• EC Number: 236-867-9
• MDL number: MFCD00010530
• Assay: ≥98% (TLC)
• Form: powder

Propiedades

• Nombre del producto: Pindolol, ≥98% (TLC), powder
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• color: white to off-white
• mp: 167-171 °C (lit.)
• solubility: 0.1 M NaOH: 0.2 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, acetic acid: 50 mg/mL, H₂O: insoluble
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: CC(C)NCC(O)COc1cccc2[nH]ccc12
• InChI: 1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
• InChI key: JZQKKSLKJUAGIC-UHFFFAOYSA-N
• Gene Information: human ... ADRB1(153), ADRB2(154), HTR1A(3350)

Descripción

Application

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Biochem/physiol Actions

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

Features and Benefits

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves