M9170
Macrophage Colony-Stimulating Factor from mouse
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sinónimos:
CSF-1
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About This Item
Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
eCl@ss:
32190102
NACRES:
NA.77
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Nombre del producto
Macrophage Colony-Stimulating Factor from mouse, M-CSF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
origen biológico
mouse
Nivel de calidad
recombinante
expressed in E. coli
Ensayo
≥98% (SDS-PAGE)
Formulario
lyophilized powder
potencia
0.500-3.000 ng/mL ED50
calidad
endotoxin tested
mol peso
dimer 18.2 kDa (containing 156 amino acid residues)
envase
pkg of 10 μg
técnicas
cell culture | mammalian: suitable
impurezas
≤1.000 EU/μg
color
white
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Csf1(12977)
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Aplicación
Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
Acciones bioquímicas o fisiológicas
Macrophage Colony Stimulating Factor (M-CSF), also known as CSF-1, can be produced by a number of cells, including fibroblasts, monocytes, activated macrophages, secretory epithelial cells of the endometrium, endothelial cells activated by LPS or cytokines, and bone marrow stromal cells. In addition to its namesake activity, M-CSF can stimulate the proliferation of isolated macrophages, augment the production and release of cytokines and other inflammatory modulators from macrophages, enhance macrophage antibody-dependent cell-mediated cytotoxicity, prime and enhance macrophages in their ability to kill tumor cells and other microorganisms, stimulate pinocytosis, and support osteoclast differentiation. M-CSF binds and activates a 165 kDa glycoprotein of the receptor tyrosine kinase subclass III or the RTK subfamily. Due to alternative splicing of a single M-CSF gene and due to variations in glycosylation, the molecular weight of natural soluble M-CSF ranges from 44-86 kDa. Human and mouse M-CSF share approximately 80% sequence homology in the conserved N-terminal region of 150 amino acids. Although human M-CSF is active in murine systems, mouse M-CSF appears to be species-specific in its actions.
Macrophage Colony Stimulating Factor (M-CSF), also known as CSF-1, can be produced by fibroblasts, monocytes, activated macrophages, secretory epithelial cells of the endometrium, endothelial cells activated by LPS or cytokines, and bone marrow stromal cells. In addition to its namesake activity, M-CSF augments many of the physiological functions of macrophages, and support osteoclast differentiation. M-CSF binds and activates a 165 kDa glycoprotein of the receptor tyrosine kinase subclass III or the RTK subfamily. Due to alternative splicing and glycosylation the molecular weight of natural soluble M-CSF ranges from 44-86 kDa. Although human M-CSF is active in murine systems, mouse M-CSF appears to be species-specific in its actions.
Forma física
Lyophilized from a sterile filtered buffered aqueous solution.
Nota de análisis
The proliferative activity is tested by the dose-dependent stimulation of the murine monocytic cell line, M-NFS-60.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Gloves
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