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M0321

Sigma-Aldrich

MDM2 human

recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE)

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

200

recombinant

expressed in E. coli

description

contains an N-terminal GST tag

assay

≥75% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~84 kDa

UniProt accession no.

Q00987

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MDM2(4193)

General description

Murine double minute 2 (MDM2) encoding gene is localized at 12q15 in the human chromosome. It is a multidomain nuclear phosphoprotein. It possesses really interesting new gene (RING) finger domain and its function and structural integrity is required for the action of MDM2. It also has central acidic domain.

Biochem/physiol Actions

Murine double minute 2 (MDM2) is a chief regulator of the p53 tumor suppressor protein. It is a multifunctional oncoprotein that contributes to both p53-dependent and -independent roles in oncogenesis. MDM2 has various p53-independent functions that contribute to its activity as an oncogene.
Overexpression of Murine double minute 2 (MDM2) is observed in various cancer like lung, gastric, colorectal, hepatocellular, breast, endometrial, and prostate. A common single nucleotide polymorphism is observed at 309 amino acid (from T to G) increases the susceptibility to cancer.
MDM2 is a negative regulator of the p53 tumor suppressor.
Mdm2 functions as an E3 ubiquitin ligase and an inhibitor of p53 transcriptional activation.

Physical form

Solution in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF and 25% glycerol.

Preparation Note

Supplied as a truncated version (202-end) with an N-terminal GST tag

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Visite la Librería de documentos

[Extracorporeal shock wave lithotripsy (ESWL) in the treatment of urolithiasis].
T Schärfe et al.
Archivos espanoles de urologia, 41(6), 455-459 (1988-07-01)
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
Poyurovsky MV, et al.
The Embo Journal, 26(1), 90-101 (2007)
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein
Sdek P, et al.
Molecular Cell, 20(5), 699-708 (2005)
Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis
Zou X, et al.
Medicine, 97(49) (2018)
C Dehay et al.
Nature, 331(6154), 348-350 (1988-01-28)
Our understanding of the development of cortical connectivity largely stems from studies of the ontogeny of interhemispheric pathways in carnivores, rodents and lagomorphs. Early in development, cortical neurons projecting to the contralateral hemisphere through the corpus callosum (callosal projection neurons)
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