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G2253

Sigma-Aldrich

L-Glutamic acid γ-monohydroxamate

≥97% (TLC)

Sinónimos:

L-γ-Glutamylhydroxamic acid, L-5-N-Hydroxyglutamine

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About This Item

Fórmula empírica (notación de Hill):
C5H10N2O4
Número de CAS:
1955-67-5
Peso molecular:
162.14
MDL number:
MFCD00057719
UNSPSC Code:
12352209
PubChem Substance ID:
24895091
NACRES:
NA.26

product name

L-Glutamic acid γ-monohydroxamate,

assay

≥97% (TLC)

Quality Level

200

form

powder

color

white to off-white

application(s)

detection

storage temp.

−20°C

SMILES string

NC(CCC(=O)NO)C(O)=O

InChI

1S/C5H10N2O4/c6-3(5(9)10)1-2-4(8)7-11/h3,11H,1-2,6H2,(H,7,8)(H,9,10)

InChI key

YVGZXTQJQNXIAU-UHFFFAOYSA-N

Application

L-Glutamic acid γ-monohydroxamate has been used as a standard to calculate transglutaminase (TGase) activity.

Biochem/physiol Actions

L-Glutamic acid γ-monohydroxamate [L-Glu(gamma)HXM] is used as a vanadium ligand which potentiates vanadiums metabolic activity. L-Glu(gamma)HXM is also used as a substrate for E. coli asparagine synthetase B and as an ATP-dependent irreversible inhibitor of Escherichia coli gamma-glutamylcysteine synthetase.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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G X Zhang et al.
Nutrition (Burbank, Los Angeles County, Calif.), 13(7-8), 652-655 (1997-07-01)
Exogenous epidermal growth factor (EGF) markedly increases the in vivo uptake of glutamine by small intestine during total parenteral nutrition (TPN). Since glutamine is the major oxidative fuel for the small intestine and is synthesized mainly in skeletal muscle, we
Yibin Xu et al.
Protein expression and purification, 34(1), 142-146 (2004-02-10)
A soluble N-terminal domain of the Escherichia coli adenylyl transferase (ATase) is responsible for deadenylylation activity of the intact enzyme. Previous studies of the deadenylylation activity have involved a fragment, AT-N423 (residues 1 to 423), which was extended by 17
Michael J Muhitch
Journal of plant physiology, 160(6), 601-605 (2003-07-23)
In maize (Zea mays L.), GSp1, the predominant GS isozyme of the developing kernel, is abundant in the pedicel and pericarp, but absent from the endosperm and embryo. Determinations of GSp1 tissue distribution in vegetative tissues have been limited thus
I Goldwaser et al.
Molecular pharmacology, 58(4), 738-746 (2000-09-22)
Several ligands, when complexed with vanadium, potentiate its insulinomimetic activity both in vivo and in vitro. We have recently found that L-Glu-gamma-monohydroxamate (HXM) and L-Asp(beta)HXM were especially potent in this regard. In the present study, we used vanadium-enriched adipose cells
I Goldwaser et al.
The Journal of biological chemistry, 274(37), 26617-26624 (1999-09-03)
We report that the vanadium ligand L-Glu(gamma)HXM potentiates the capacity of free vanadium ions to activate glucose uptake and glucose metabolism in rat adipocytes in vitro (by 4-5-fold) and to lower blood glucose levels in hyperglycemic rats in vivo (by
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