D2521

(+)-cis-Diltiazem hydrochloride

≥99% (HPLC)

• Sinónimos: (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401
• Fórmula empírica (notación de Hill): C₂₂H₂₆N₂O₄S · HCl
• Número de CAS: 33286-22-5
• Peso molecular: 450.98
• Beilstein: 4228706
• Número CE: 251-443-3
• Número MDL: MFCD00069252
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277849
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥99% (HPLC)
• Formulario: powder
• emisor: Valeant
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
• InChI: 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
• Clave InChI: HDRXZJPWHTXQRI-BHDTVMLSSA-N
• Información sobre el gen: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

Descripción

Descripción general

Diltiazem hydrochloride is used to treat cardiovascular diseases, such as angina and hypertension. It acts as an inhibitor to cytochrome P450 3A (CYP3A). Diltiazem might be associated with maculopapular rashes, urticaria and pruritus.

Aplicación

(+)-cis-Diltiazem hydrochloride has been used:

• to study its effects on diffusion and release in monolithic dispersion matrix(26)
• to study its neuroprotective effects in retinitis pigmentosa (RP) models(27)
• as an antagonist against the Cav1.2 L-type calcium channels (LTCCs)(28)

Acciones bioquímicas o fisiológicas

Blocks slow, or L-type Ca²⁺ channels; regulates Ca²⁺ release from intracellular stores in neutrophils; stimulates 1,4-dihydropyridine binding to Ca²⁺ channels; coronary vasodilator.

Características y beneficios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Calcium Channels and Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 + P330 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves