The solution stability of this product has not been determined. However, historical data suggest that solutions in methanol are stable for several weeks when stored refrigerated and protect from light. Manufacturers of aqueous solutions in sodium chloride for therapeutic use indicate a shelf life of 6 months when stored refrigerated and protect from light.
V4629
(±)-Verapamil hydrochloride
≥99% (titration), powder, α1-adrenoceptor antagonist
Sinónimos:
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
1 g | Comprobar disponibilidad del carrito | $88.000 |
5 g | Comprobar disponibilidad del carrito | $354.000 |
10 g | Comprobar disponibilidad del carrito | $613.000 |
Acerca de este artículo
Fórmula lineal:
(CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
Número CAS:
Peso molecular:
491.06
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-800-5
MDL number:
Beilstein/REAXYS Number:
3647093
Assay:
≥99% (titration)
Form:
powder
Servicio técnico
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Permítanos ayudarleNombre del producto
(±)-Verapamil hydrochloride, ≥99% (titration), powder
Quality Segment
assay
≥99% (titration)
form
powder
color
white
mp
142 °C (dec.) (lit.)
solubility
methanol: 50 mg/mL, ethanol: soluble
SMILES string
Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI
1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChI key
DOQPXTMNIUCOSY-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
Application
Verapamil hydrochloride has been used:
Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker.
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Este artículo | |||
|---|---|---|---|
| form powder | form - | form solid | form liquid |
| assay ≥99% (titration) | assay - | assay ≥99% (perchloric acid titration) | assay - |
| Quality Level 100 | Quality Level 300 | Quality Level 100 | Quality Level 300 |
| solubility methanol: 50 mg/mL, ethanol: soluble | solubility - | solubility methanol: 50 mg/mL, water: 70 mg/mL, ethanol: soluble | solubility - |
| color white | color - | color white | color - |
| mp 142 °C (dec.) (lit.) | mp 142 °C (dec.) (lit.) | mp - | mp - |
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Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 2
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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