C1988

Cicloheximida

Biotechnology Performance Certified

• Sinónimos: 3-[2-(3,5- Dimetil-2-oxociclohexil)-2-hidroxietil]glutarimida, Actidiona, Naramicina A
• Fórmula empírica (notación de Hill): C₁₅H₂₃NO₄
• Número CAS: 66-81-9
• Peso molecular: 281.35
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 24892457
• EC Number: 200-636-0
• Beilstein/REAXYS Number: 88868
• MDL number: MFCD00082346

Propiedades

• grade: Biotechnology Performance Certified
• Quality Segment: 200
• form: powder
• technique(s): cell culture | mammalian: suitable
• antibiotic activity spectrum: fungi, yeast
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• InChI key: YPHMISFOHDHNIV-FSZOTQKASA-N
• Gene Information: human ... FKBP1A(2280), PIN1(5300)

Descripción

Application

Cycloheximide is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques[1] and activate cumulus-free equine oocytes.[2]

Biochem/physiol Actions

Modo de acción: inhibición de la traducción en eucariotas que provoca la detención del crecimiento celular y la muerte celular. La CHX se utiliza ampliamente para la selección de cepas de levaduras y hongos resistentes a CHX, la inhibición controlada de la síntesis de proteínas para la detección de proteínas de vida corta y la súper-inducción de la expresión de proteínas, así como la inducción de la apoptosis o la facilitación de la inducción de la apoptosis por los receptores de muerte.

Espectro de actividad: activo contra levaduras y hongos como Candida, Aspergillus, Saccharomyces y Penicillium

Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. It inactivate transferase II enzyme that is involved in peptide chain elongation.[3] More recent studies revealed that CHX binds the 60S ribosome and specifically prevents the translocation step in elongation.[4]

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Información de seguridad

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H300,H341,H360D,H411
• pcodes: P201 - P202 - P264 - P270 - P273 - P301 + P310
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges