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Merck
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Documentos

A4929

Supelco

N,N′-Bis(acryloyl)cystamine

BioReagent, suitable for electrophoresis

Sinónimos:

2,2′-(Bisacrylamino)diethyl disulfide, BAC, Bis(2-acrylamidoethyl) disulfide

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About This Item

Fórmula empírica (notación de Hill):
C10H16N2O2S2
Número de CAS:
60984-57-8
Peso molecular:
260.38
EC Number:
262-546-8
MDL number:
MFCD00036225
UNSPSC Code:
12352116
PubChem Substance ID:
24890926
NACRES:
NA.25

product line

BioReagent

Quality Level

200

form

powder

suitability

suitable for electrophoresis

storage temp.

−20°C

SMILES string

C=CC(=O)NCCSSCCNC(=O)C=C

InChI

1S/C10H16N2O2S2/c1-3-9(13)11-5-7-15-16-8-6-12-10(14)4-2/h3-4H,1-2,5-8H2,(H,11,13)(H,12,14)

InChI key

DJVKJGIZQFBFGS-UHFFFAOYSA-N

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Categorías relacionadas

Application

BAC is used as a reversible cross-linker for polyacrylamide gels, to simplify isolation of macromolecules separated on the gels. The disulfide linkage can be broken with a suitable reducing agent. A 1-g slice of a 4% (12:1) gel will dissolve in 5 mL of 100 mM DTT in TBE (pH 8.3) in less than 30 min.
BAC is used as a reversible cross-linker for polyacrylamide gels. The disulfide linkage can be broken with a suitable reducing agent. A 12:1 ratio of acrylamide:BAC is recommended for DNA purification. A one gram slice of a 4% gel will dissolve in 5 mL of 100 mM DTT, TBE solution (pH 8.3) in less than 30 min. The pH of 8.3 is optimum for rapid dissolution of the gel.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Nick Orr et al.
Human molecular genetics, 24(10), 2966-2984 (2015-02-06)
We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 controls of European ancestry ascertained from 52
David W Cescon et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(11), 2499-2505 (2015-03-06)
Genomic profiling of lung squamous cell carcinomas (SCC) has identified NRF2 pathway alterations, which activate oxidative response pathways, in one third of tumors. Preclinical data suggest these tumors may be resistant to platinum-based chemotherapy. We evaluated the clinical relevance of
Na-Yu Chia et al.
Gut, 64(5), 707-719 (2014-07-24)
Gastric cancer (GC) is a deadly malignancy for which new therapeutic strategies are needed. Three transcription factors, KLF5, GATA4 and GATA6, have been previously reported to exhibit genomic amplification in GC. We sought to validate these findings, investigate how these
Kevin R Bushell et al.
Blood, 125(6), 999-1005 (2014-12-04)
Non-Hodgkin lymphomas (NHLs) are the most common cancer to affect pet dogs. In contrast to the many genes whose mutation contributes to lymphomagenesis in humans, relatively little is known about the acquired genetic alterations that lead to canine B-cell lymphomas
Hiroko Sano et al.
PLoS genetics, 11(5), e1005209-e1005209 (2015-05-29)
The coordination of growth with nutritional status is essential for proper development and physiology. Nutritional information is mostly perceived by peripheral organs before being relayed to the brain, which modulates physiological responses. Hormonal signaling ensures this organ-to-organ communication, and the
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