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Merck
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Key Documents

A3737

Sigma-Aldrich

Cefepime hydrochloride

Sinónimos:

Cefepime dihydrochloride monohydrate

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About This Item

Fórmula lineal:
C19H25N6O5S2Cl · HCl · H2O
Número de CAS:
123171-59-5
Peso molecular:
571.50
UNSPSC Code:
51282610
NACRES:
NA.85

form

powder

Quality Level

200

color

white to faint yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

−20°C

InChI

1S/C19H24N6O5S2.2ClH.H2O/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11;;;/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29);2*1H;1H2/b23-12-;;;/t13-,17-;;;/m1.../s1

InChI key

LRAJHPGSGBRUJN-OMIVUECESA-N

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General description

Cefepime is a semi-synthetic fourth-generation cephalosporin. It is resistant to hydrolysis by common plasmid and/or chromosomally-mediated β-lactamases.

Application

Cefepime was used in antimicrobial susceptibility testing for Acinetobacter baumannii and extended-spectrum-β-lactamase-producing Escherichia coli isolated from various samples.

Biochem/physiol Actions

Cefepime is a broad-spectrum cephalosporin with activity against Gram-positive and Gram-negative bacteria. It binds to penicillin-binding proteins and disrupts the cell wall synthesis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kuei-Hsiang Hung et al.
Journal of clinical microbiology, 50(3), 721-726 (2011-12-23)
Heteroresistance to antimicrobial agents may affect susceptibility test results and therapeutic success. In this study, we investigated heteroresistance to cephalosporins and penicillins in Acinetobacter baumannii, a major pathogen causing nosocomial infections. Two A. baumannii isolates exhibited heteroresistance to ampicillin-sulbactam, ticarcillin-clavulanic
Nathaniel J Rhodes et al.
Antimicrobial agents and chemotherapy, 58(7), 3757-3761 (2014-04-23)
While a lack of concordance is known between gold standard MIC determinations and Vitek 2, the magnitude of the discrepancy and its impact on treatment decisions for extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli are not. Clinical isolates of ESBL-producing E. coli were
L B Barradell et al.
Drugs, 47(3), 471-505 (1994-03-01)
Cefepime is a 'fourth' generation cephalosporin that has a broader spectrum of antibacterial activity than the third generation cephalosporins and is more active in vitro against Gram-positive aerobic bacteria. The fact that cefepime is stable to hydrolysis by many of
M P Okamoto et al.
American journal of hospital pharmacy, 51(4), 463-477 (1994-02-15)
The chemistry, pharmacology, antimicrobial spectrum, pharmacokinetics, clinical efficacy, adverse effects, and dosage of cefepime are reviewed. Fourth-generation cephalosporins, such as cefepime, have a quaternary nitrogen that is positively charged at the 3-position, providing the properties of a zwitterion. A 2-aminothiazolyl-acetamido
Fu Peng et al.
Chinese medical journal, 127(23), 4001-4005 (2014-11-29)
Our pervious antibacterial studies on several traditional Chinese medicines have found that Patchouli oil from Pogostemon cablin had significant antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), which has spread worldwide and infected innumerable people. In order to find the more
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