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Merck

Y0001553

Ciclesonide

European Pharmacopoeia (EP) Reference Standard

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About This Item

Fórmula empírica (notación de Hill):
C32H44O7
Número de CAS:
Peso molecular:
540.69
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

ciclesonide

packaging

pkg of 150 mg

manufacturer/tradename

EDQM

storage condition

protect from light

color

white

bp

665.0 °C/1.333 hPa (1229.0°F)

mp

209-211 °C (408—412°F)

solubility

water: <0.1 g/L
acetone: soluble
ethanol: soluble

density

1.23 g/cm3 at 20 °C (1.333 hPa)

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

ambient

Storage temp.

2-8°C

SMILES string

C[C@@]12C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@]4(O[C@@](C6CCCCC6)([H])O5)C(COC(C(C)C)=O)=O)=CC(C=C1)=O

InChI

1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1

Inchi Key

LUKZNWIVRBCLON-GXOBDPJESA-N

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General description

Ciclesonide is a new-generation, non-halogenated glucocorticoid. It is a prodrug that releases an active primary metabolite, ciclesonide−active principle (CIC-AP), on enzymatic cleavage.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Visite la Librería de documentos

Forced degradation study to develop and validate stability-indicating RP-LC method for the determination of ciclesonide in bulk drug and metered dose inhalers
Elkady EF and Fouad MA
Talanta, 87, 222-229 (2011)
Sensitive LC method for simultaneous determination of ciclesonide and formoterol fumarate in dry powder inhaler
Patil AT, et al.
Journal of Liquid Chromatography and Related Technologies, 34(15), 1568-1577 (2011)
RP-HPLC method for simultaneous estimation of formoterol fumarate, tiotropium bromide and ciclesonide in pharmaceutical metered dose inhalers
Pulla RP, et al.
Asian Journal of Research in Chemistry, 4(4), 585-590 (2011)
Population pharmacokinetics and pharmacodynamics of ciclesonide
Rohatagi S, et al.
Journal of Clinical Pharmacology, 43(4), 365-378 (2003)
New Drugs for Asthma, Allergy and COPD, 42, 42-54 (2001)

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