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Y0000824

Niflumic acid

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid, 2-[3-(Trifluoromethyl)anilino]nicotinic acid

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About This Item

Fórmula empírica (notación de Hill):
C13H9F3N2O2
Número de CAS:
4394-00-7
Peso molecular:
282.22
Número MDL:
MFCD00010569
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329831173
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

niflumic acid

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O=C(O)C1=CC=CN=C1NC2=CC(C(F)(F)F)=CC=C2

InChI

1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)

Clave InChI

JZFPYUNJRRFVQU-UHFFFAOYSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Niflumic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Selective cyclooxygenase-2 (COX-2) inhibitor.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Precios

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301,H413

Clasificaciones de peligro

Acute Tox. 3 Oral - Aquatic Chronic 4

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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J L Cousin et al.
The Journal of membrane biology, 46(2), 125-153 (1979-04-20)
In human erythrocyte, permeability to the anion is instantaneously, reversibly, and noncompetitively inhibited by the nonsteroidal anti-inflammatory drug, niflumic acid. The active form of this powerful inhibitor (I50 = 6 X 10(-7) M) is the ionic form. We demonstrated that:
Sayo Matsuba et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 510-518 (2014-09-19)
The Ca(2+)-activated Cl(-) channel transmembrane proteins with unknown function 16 A (TMEM16A; also known as anoctamin 1 or discovered on gastrointestinal stromal tumor 1) plays an important role in facilitating the cell growth and metastasis of TMEM16A-expressing cancer cells. Histone
Paola Imbrici et al.
Biochimica et biophysica acta, 1838(10), 2484-2491 (2014-05-28)
CLC-K chloride channels play a crucial role in kidney physiology and genetic mutations, affecting their function are responsible for severe renal salt loss in humans. Thus, compounds that selectively bind to CLC-Ka and/or CLC-Kb channels and modulate their activity may
Pablo Ávalos Prado et al.
Cell, 184(2), 534-544 (2020-12-30)
Determination of what is the specificity of subunits composing a protein complex is essential when studying gene variants on human pathophysiology. The pore-forming α-subunit KCNQ1, which belongs to the voltage-gated ion channel superfamily, associates to its β-auxiliary subunit KCNE1 to
Kelly M Adams et al.
PloS one, 9(8), e103263-e103263 (2014-08-21)
The epithelium plays an active role in the response to inhaled pathogens in part by responding to signals from the immune system. Epithelial responses may include changes in chemokine expression, increased mucin production and antimicrobial peptide secretion, and changes in
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