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S0929

Sigma-Aldrich

Scopolamine hydrobromide

meets USP testing specifications

Sinónimos:

(−)-Scopolamine hydrobromide trihydrate, Hyoscine hydrobromide, Scopine tropate

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1 G
$109.000
5 G
$360.000
25 G
$1.480.000

$109.000

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1 G
$109.000
5 G
$360.000
25 G
$1.480.000

About This Item

Fórmula empírica (notación de Hill):
C17H21NO4 · HBr · 3H2O
Número de CAS:
6533-68-2
Peso molecular:
438.31
Beilstein:
6100669
Número MDL:
MFCD00150066
Código UNSPSC:
12352116
ID de la sustancia en PubChem:
24899453
NACRES:
NA.21

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Agency

USP/NF
meets USP testing specifications

Nivel de calidad

200

mp

195-199 °C (dry matter) (lit.)

aplicaciones

pharmaceutical (small molecule)

cadena SMILES

O.O.O.Br.CN1[C@@H]2C[C@H](C[C@H]1[C@@H]3O[C@H]23)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.BrH.3H2O/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;;;;/h2-6,11-16,19H,7-9H2,1H3;1H;3*1H2/t11-,12-,13-,14+,15-,16+;;;;/m1..../s1

Clave InChI

LACQPOBCQQPVIT-SEYKEWMNSA-N

Información sobre el gen

human ... CHRM1(1128)

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Categorías relacionadas

Aplicación

Scopolamine hydrobromide has been used as a muscarinic receptor antagonist:
  • to reverse the cardiac effects of physostigmine in rabbit heart[1]
  • to study its effect on acoustic startle reflex (gap-PPI){148)
  • to study it′s in vitro antiviral, antibacterial, and antifungal activities and cytotoxicity[2]
  • to study its effect on conditioning of lever pressing[3]

Acciones bioquímicas o fisiológicas

Competitive nonselective muscarinic acetylcholine antagonist.
Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H300 + H310 + H330

Clasificaciones de peligro

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000281189
0000281202
SLCP6341
0000281201
0000281189

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Bardia Nouriziabari et al.
Journal of Alzheimer's disease : JAD, 63(2), 725-740 (2018-04-18)
Trace eyeblink conditioning is a hippocampus-dependent associative learning paradigm which is impaired in patients with Alzheimer's disease (AD) and animal AD models. Learning in this paradigm accompanies changes in oscillatory activity in forebrain regions, some of which are loci of
Reversal of cardiac vagal effects of physostigmine by adjunctive muscarinic blockade
Winter J, et al.
Neurotoxicology, 57, 174-182 (2016)
Effects of Scopolamine on Conditioning of Lever Pressing
Juarez Y, et al.
Acta Acad. Med. Sin., 1(1), 14-23 (2011)
Gareth R I Barker et al.
Learning & memory (Cold Spring Harbor, N.Y.), 16(1), 8-11 (2009-01-02)
Object-in-place memory, which relies on the formation of associations between an object and the place in which it was encountered, depends upon a neural circuit comprising the perirhinal (PRH) and medial prefrontal (mPFC) cortices. This study examined the contribution of
Patrizia Giannoni et al.
The Journal of pharmacology and experimental therapeutics, 332(1), 164-172 (2009-10-10)
After oral administration, the nonimidazole histamine H(3) receptor antagonist, 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254), increased histamine release from the tuberomammillary nucleus, where all histaminergic somata are localized, and from where their axons project to the entire brain. To further understand functional histaminergic
Ver todos los artículos relacionados

Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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