ALD00602

(–)-PSI Reagent

95%

• Sinónimos: (2S,3aS,6R,7aS)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, (–)-Ψ, Phosphorus-Sulfur Incorporation Reagent
• Fórmula empírica (notación de Hill): C₁₆H₁₆F₅OPS₃
• Número de CAS: 2245335-70-8
• Peso molecular: 446.46
• Número MDL: MFCD32068365
• Código UNSPSC: 12352101
• NACRES: NA.22

Propiedades

• Ensayo: 95%
• Formulario: powder or crystals
• mp: 103-107 °C
• cadena SMILES: Fc1c(c(c(c(c1F)F)S[P]2(=S)S[C@@]3([C@@H](O2)C[C@@H](CC3)C(=C)C)C)F)F
• InChI: 1S/C16H16F5OPS3/c1-7(2)8-4-5-16(3)9(6-8)22-23(24,26-16)25-15-13(20)11(18)10(17)12(19)14(15)21/h8-9H,1,4-6H2,2-3H3/t8-,9+,16+,23?/m1/s1
• Clave InChI: YPYCUYPOHPPYAS-QSHUGKRNSA-N

Descripción

Aplicación

Air- and moisture-tolerant, this (-)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (+)-PSI Reagent, is also available (cat# ALD00604).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Otras notas

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

PSI on OpenFlask

Información legal

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable