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Merck

89802

Supelco

4-(Dimethylamino)azobenzene-4′-sulfonyl chloride

for HPLC derivatization, LiChropur, 98.0-102.0% (AT)

Sinónimos:

4-(4-Dimethylaminophenylazo)benzenesulfonyl chloride, DABS-Cl, Dabsyl chloride

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About This Item

Fórmula lineal:
(CH3)2NC6H4N=NC6H4SO2Cl
Número de CAS:
Peso molecular:
323.80
Beilstein:
3064095
Número CE:
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.22

grado

for HPLC derivatization

Nivel de calidad

Ensayo

98.0-102.0% (AT)

Formulario

crystals

calidad

LiChropur

técnicas

HPLC: suitable

mp

185 °C (dec.) (lit.)

cadena SMILES

CN(C)c1ccc(cc1)\N=N\c2ccc(cc2)S(Cl)(=O)=O

InChI

1S/C14H14ClN3O2S/c1-18(2)13-7-3-11(4-8-13)16-17-12-5-9-14(10-6-12)21(15,19)20/h3-10H,1-2H3/b17-16+

Clave InChI

VTVWTPGLLAELLI-WUKNDPDISA-N

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Descripción general

Amino groups are common to many biological compounds and many amines used in pharmaceuticals. Most of these compounds show weak absorption in direct HPLC analysis with UV-VIS detection. However, strongly absorbing derivatives of amines can be easily detected by HPLC with high sensitivity even when present at low concentrations. Primary and secondary amino groups are usually derivatized as aromatic derivatives by nucleophilic substitution reactions using reagents such as arylsulfonyl chlorides.
4-(Dimethylamino)azobenzene-4′-sulfonyl chloride, a well-known UV-labeling agent, is generally used for the derivatization of N-terminal amino acids, imidazole derivatives, polyamines, etc. prior to their chromatographic determination due to the former′s capacity to covalently bind to the substrates. Its derivatives typically absorb UV radiation between the range of 436-460 nm. This method of derivatization is regarded as superior compared to other methods owing to the simplicity of the procedure, high stability and reproducibility, best resolution of the analytes, etc.

Aplicación

4-(Dimethylamino)azobenzene-4′-sulfonyl chloride may be used to derivatize biogenic amines, primary amino acids, melamine, and hydroxyproline and proline extracted from various biological samples prior to their determination using high performance liquid chromatography (HPLC) technique to increase their detection sensitivity.

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Información legal

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Corrosion

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Skin Corr. 1B

Código de clase de almacenamiento

8A - Combustible corrosive hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Visite la Librería de documentos

Journal of Chromatography Library
J. Chromatogr. Library, 70(2), 229-241 (2005)
Sensitive determination of melamine in milk and powdered infant formula samples by high-performance liquid chromatography using dabsyl chloride derivatization followed by dispersive liquid-liquid microextraction
Faraji M and Adeli M
Food Chemistry, 221, 139-146 (2017)
Microcharacterization of Proteins
J. Chromatogr. Library, 70(2), 229-241 (2005)
Kellner R, et al.
Microcharacterization of Proteins., 70(2), 229-241 (2008)
Reversed-phase high-performance liquid chromatographic analysis of hydroxyproline and proline from collagen by derivatization with dabsyl chloride
Ikeda M. et al.
Journal of Chromatography. B, Biomedical Applications, 621(2), 133-138 (1993)

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