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Merck

59924

Sigma-Aldrich

TWEEN® 80

tested according to Ph. Eur.

Sinónimos:

Monooleato de POE (20) sorbitano, Monooleato de polietilenglicol sorbitano, Monooleato de polioxietilen sorbitano, Polisorbato 80

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100 G
$39.800
1 KG
$165.000

$39.800


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100 G
$39.800
1 KG
$165.000

About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12161900
NACRES:
NA.21

$39.800


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Agency

USP/NF
tested according to Ph. Eur.

Nivel de calidad

presión de vapor

<1 mmHg ( 20 °C)

descripción

non-ionic

Formulario

liquid

mol peso

average mol wt 79,000

número de agregación

60

índice de refracción

n20/D 1.472 (lit.)

CMC

0.012

temperatura de transición

cloud point 65 °C

densidad

1.064 g/mL at 25 °C (lit.)

HLB

15

aplicaciones

pharmaceutical (small molecule)

cadena SMILES

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

Clave InChI

RGPBUVUVZKQNHD-MDZDMXLPSA-N

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Descripción general

Polysorbate 80 is a surfactant.[1] Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.[2]

Aplicación

Polysorbate 80 has been used in drug (rapamycin) treatment[3][4] and to study the effect of rapamycin on osteolysis and tumor growth.[3] It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.[5]

Acciones bioquímicas o fisiológicas

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.[2]

Información legal

TWEEN is a registered trademark of Croda International PLC

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves


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Radiation therapy is a cornerstone of modern management methods for malignancies but is accompanied by diverse side effects. In the present study, we showed that food additives such as polysorbate 80 (P80) exacerbate irradiation-induced gastrointestinal (GI) tract toxicity. A 16S
Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases
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Characterizing protein aggregates in the presence of silicone oil is a long standing challenge for the pharmaceutical industry. Silicone oil is often used as a lubricant in devices that deliver and store therapeutic protein products and has been linked to

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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