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345757

Sigma-Aldrich

Anti-Ganglioside GM₁ Rabbit pAb

liquid, Calbiochem®

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

form

liquid

does not contain

preservative

species reactivity (predicted by homology)

all

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG

shipped in

wet ice

Storage temp.

−20°C

target post-translational modification

unmodified

General description

Anti-Ganglioside GM₁, rabbit polyclonal, recognizes ganglioside GM₁. Cross-reacts slightly with asialo-GM₁. ELISA and TLC immunoblotting.
Rabbit polyclonal antibody supplied as undiluted serum. Recognizes ganglioside GM1.
Recognizes ganglioside GM1. Cross-reacts slightly with asialo-GM1. Note: IB refers to TLC-IB.

Immunogen

Bovine
purified, bovine ganglioside GM₁

Application

ELISA (see comments)

TLC Immunoblotting (1:1000, colormetric)

Warning

Toxicity: Standard Handling (A)

Physical form

Undiluted serum.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Cross-reacts slightly with asialo-GM1. Does not cross-react with other carbohydrate epitopes. Product is not to be used for animal treatment, in vivo research, or in any other contact procedure with livestock. This antibody has also been reported to work for ELISA. Variables associated with assay conditions will dictate the optimal working dilution.
Yoshino, H., et al. 1993. J. Neurochem.61, 658.
Kusunoki, S., et al. 1987. Neurology37, 1795.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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International journal of molecular sciences, 19(2) (2018-02-23)
Juvenile neuronal ceroid lipofuscinosis (JNCL) is caused by mutations in the CLN3 gene. Most JNCL patients exhibit a 1.02 kb genomic deletion removing exons 7 and 8 of this gene, which results in a truncated CLN3 protein carrying an aberrant
Danny Galleguillos et al.
Journal of neuroinflammation, 19(1), 9-9 (2022-01-08)
Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects in the ganglioside biosynthetic pathway result in severe neurodegenerative diseases, while a partial decrease in the levels of specific gangliosides
Neha Singhal et al.
Skeletal muscle, 5, 3-3 (2015-02-24)
Cell surface glycans are known to play vital roles in muscle membrane stability and muscle disease, but to date, roles for glycans in muscle regeneration have been less well understood. Here, we describe a role for complex gangliosides synthesized by

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