345733-M

Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk

Contains mainly N-acetylneuraminic acid.

• Sinónimos: Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk, Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
• Fórmula empírica (notación de Hill): C₆₄H₁₁₈N₂O₂₁ · NH₄
• Peso molecular: 1269.66
• UNSPSC Code: 12352211

Propiedades

• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: chloroform/methanol (2:1): soluble
• storage temp.: −20°C

Descripción

General description

Contains mainly N-acetylneuraminic acid. GM₃ and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM₃ is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC₅₀ = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.

Contains mainly N-acetylneuraminic acid. GM₃ and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC₅₀ = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.

M.W. 1198.5 (based on stearoyl - 18:0).

Biochem/physiol Actions

Primary Target
Protein kinase C, EGF-receptor tyrosine kinase

Target IC₅₀: 100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions

Warning

Toxicity: Irritant (B)

Other Notes

Katoh, N. 1995. Life Sci. 56, 157.
Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable