860065P

Ganglioside GM1 (Ovine Brain)

Avanti Research^™ - A Croda Brand

• Sinónimos: 110952
• Número de CAS: 37758-47-7
• MDL number: MFCD00466936
• UNSPSC Code: 12352211
• NACRES: NA.25

Propiedades

• description: GM1 Ganglioside (Brain, Ovine-Sodium Salt)
• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (860065P-1mg); pkg of 1 × 10 mg (860065P-10mg); pkg of 1 × 25 mg (860065P-25mg); pkg of 1 × 5 mg (860065P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: sphingolipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O[C@@H]4O[C@H](CO)[C@@H]([C@H](O[C@@H]5O[C@H
• InChI: 1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(86)76-44(45(83)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-99-69-61(93)59(91)63(50(38-79)102-69)104-71-62(94)67(98-41-47(85)55(87)66-53(74-42(3)81)46(84)35-73(97,107-66)72(95)96)64(51(39-80)103-71)105-68-54(75-43(4)82)65(57(89)49(37-78)100-68)106-70-60(92)58(90)56(88)48(36-77)101-70/h31,33,44-51,53-71,77-80,83-85,87-94,97H,5-30,32,34-41H2,1-4H3,(H,74,81)(H,75,82)(H,76,86)(H,95,96)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1
• InChI key: CNLVNZJJSHZYAS-ALSOZVJRSA-N

Descripción

General description

Ganglioside GM1 is referred as brain ganglioside. It is an acidic glycosphingolipid comprising N-acetylneuraminic acid or N-glycolylneuraminic acid residues. It is upregulated in developing brain.[1] Ganglioside GM1 has five glycosyl units.[2]

Application

Ganglioside GM1 (Ovine Brain) has been used in the preparation of small unilamellar vesicles for fluorescence studies.[3] It has also been used in liposome preparation for circular dichroism studies with human wild type−synuclein.[4] It may be used as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis.[5]

Biochem/physiol Actions

Ganglioside GM1 is a modulator of Ca²⁺ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality.[2] GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease.[6] Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis.[7]

Packaging

5 mL Amber Glass Screw Cap Vial (860065P-10mg)

5 mL Amber Glass Screw Cap Vial (860065P-1mg)

5 mL Amber Glass Screw Cap Vial (860065P-25mg)

5 mL Amber Glass Screw Cap Vial (860065P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable