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870602C

Avanti

PGPC

Avanti Research™ - A Croda Brand 870602C

Sinónimos:

1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine

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About This Item

Fórmula empírica (notación de Hill):
C29H56NO10P
Número de CAS:
89947-79-5
Peso molecular:
609.73
Número MDL:
MFCD05863933
Código UNSPSC:
12352211
NACRES:
NA.25

Formulario

liquid

envase

pkg of 1 × 1 mL (870602C-1mg)
pkg of 1 × 1 mL (870602C-5mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 870602C

concentración

1 mg/mL (870602C-1mg)
5 mg/mL (870602C-5mg)

tipo de lípido

phospholipids
phosphoglycerides

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O

Clave InChI

CDZVJFRXJAUXPP-AREMUKBSSA-N

Aplicación

PGPC (1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine) may be used as a standard in mass spectrometry analysis of phospholipids and oxidized phospholipids.

Acciones bioquímicas o fisiológicas

1-palmitoyl-2-glutaroyl-sn-glycero-phosphocholine (PGPC) is a truncated oxidized phospholipid (Tr-OxPL). It elicits endothelial barrier disruption. PGPC exhibits proinflammatory properties and increases the production of protective enzyme such as heme oxygenase 1. It acts as a precursor for the synthesis of 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphoethanolamine (PGPE). PGPC stimulates apoptotic signaling in vascular smooth muscle cells (VSMCs).

Envase

5 mL Clear Glass Sealed Ampule (870602C-1mg)
5 mL Clear Glass Sealed Ampule (870602C-5mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Órganos de actuación

Liver,Kidney, Respiratory system

Código de clase de almacenamiento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

does not flash

Punto de inflamabilidad (°C)

does not flash

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Certificados de análisis (COA)

Lot/Batch Number

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Pratap Karki et al.
PloS one, 13(11), e0206251-e0206251 (2018-11-13)
Particulate matter (PM) air pollution is a global environmental health problem contributing to more severe lung inflammation and injury. However, the molecular and cellular mechanisms of PM-induced exacerbation of lung barrier dysfunction and injury are not well understood. In the
Corinne M Spickett et al.
Free radical biology & medicine, 51(12), 2133-2149 (2011-10-11)
Phospholipids are complex and varied biomolecules that are susceptible to lipid peroxidation after attack by free radicals or electrophilic oxidants and can yield a large number of different oxidation products. There are many available methods for detecting phospholipid oxidation products
Alexandra Moumtzi et al.
Journal of lipid research, 48(3), 565-582 (2006-12-01)
Lipid oxidation is now thought to be an initiating and sustaining event in atherogenesis. Oxidatively fragmented phospholipids, namely 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), present in minimally modified LDL and atherosclerotic lesions, have been reported to elicit a wide range of
Mario Brameshuber et al.
Biophysical journal, 110(1), 205-213 (2016-01-09)
We previously developed a single-molecule microscopy method termed TOCCSL (thinning out clusters while conserving stoichiometry of labeling), which allows for direct imaging of stable nanoscopic platforms with raft-like properties diffusing in the plasma membrane. As a consensus raft marker, we
Marco Di Gioia et al.
Nature immunology, 21(1), 42-53 (2019-11-27)
Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-encoded damage-associated molecular patterns (DAMPs) induce inflammatory gene expression. However

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