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855475P

Avanti

12:0 Lyso PC

1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine, powder

Sinónimos:

1-dodecanoyl-sn-glycero-3-phosphocholine; PC(12:0/0:0)

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25 MG
$119.000
200 MG
$226.000

$119.000

Fecha estimada de envío03 de abril de 2025

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25 MG
$119.000
200 MG
$226.000

About This Item

Fórmula empírica (notación de Hill):
C20H42NO7P
Número de CAS:
20559-18-6
Peso molecular:
439.52
MDL number:
MFCD00133434
UNSPSC Code:
51191904
NACRES:
NA.25

$119.000

Fecha estimada de envío03 de abril de 2025

Solicitar un pedido a granel

assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

powder

packaging

pkg of 1 × 200 mg (855475P-200mg)
pkg of 1 × 25 mg (855475P-25mg)
pkg of 1 × 500 mg (855475P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 855475P

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCC)=O

InChI

1S/C20H42NO7P/c1-5-6-7-8-9-10-11-12-13-14-20(23)26-17-19(22)18-28-29(24,25)27-16-15-21(2,3)4/h19,22H,5-18H2,1-4H3/t19-/m1/s1

Inchi Key

BWKILASWCLJPBO-LJQANCHMSA-N

General description

Lyso-phosphatidylcholine (LPC) is a bioactive proinflammatory lipid secreted on pathological response.[1] It has a choline group at its polar head.[2] Lysophosphatidylcholine (Lyso-PC) is a component of blood plasma, vascular tissue and lipoproteins.[3]

Application

12:0 Lyso PC has been used to study its neuritogenic activity[4] and the applications of exogenous lipids.[5]

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) alters various functions in different cell-types, like endothelial cells, smooth muscle cells, monocytes, macrophages and T-cells. It is associated with atherosclerosis and inflammatory diseases. LPC activates many second messengers including, protein kinase C, extracellular-signal-regulated kinases and protein tyrosine kinases.[1]

Packaging

20 mL Clear Glass Screw Cap Vial (855475P-500mg)
5 mL Amber Glass Screw Cap Vial (855475P-200mg)
5 mL Amber Glass Screw Cap Vial (855475P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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Inner/outer nuclear membrane fusion in nuclear pore assembly: biochemical demonstration and molecular analysis
Fichtman B, et al.
Molecular Biology of the Cell, 21(23) (2010)
Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor
Ikeno Y, et al.
Test, 280(30) (2005)
Boris Fichtman et al.
Molecular biology of the cell, 21(23), 4197-4211 (2010-10-12)
Nuclear pore complexes (NPCs) are large proteinaceous channels embedded in double nuclear membranes, which carry out nucleocytoplasmic exchange. The mechanism of nuclear pore assembly involves a unique challenge, as it requires creation of a long-lived membrane-lined channel connecting the inner
Shi-Yuan Wen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 69, 152690-152690 (2018-11-06)
Rhodioloside is a glucoside of tyrosol isolated from Rhodiola rosea. However, its regulating effect on hepatic dyslipidemia of atherogenic mice has rarely been studied. The specific aims of current study included to clarify lipidomic perturbation in liver tissues of apolipoprotein
Yutaka Ikeno et al.
The Journal of biological chemistry, 280(30), 28044-28052 (2005-06-02)
We previously demonstrated that secretory phospholipase A2 (sPLA2) and lysophosphatidylcholine (LPC) exhibit neurotrophin-like neuritogenic activity in the rat pheochromocytoma cell line PC12. In this study, we further analyzed the mechanism whereby sPLA2 displays neurite-inducing activity. Exogenously added mammalian group X
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