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700184M

Avanti

desmosterol (D6) ester

26,26,26,27,27,27-hexadeuteriocholesta-5,24-dien-3β-ol (9Z-octadecenoate), methylene chloride solution

Sinónimos:

111014

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1 MG
$140.000

$140.000

Fecha estimada de envío22 de abril de 2025

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1 MG
$140.000

About This Item

Fórmula empírica (notación de Hill):
C45H70D6O2
Número de CAS:
2260669-31-4
Peso molecular:
655.12
MDL number:
MFCD00133427
UNSPSC Code:
12352211
NACRES:
NA.12

$140.000

Fecha estimada de envío22 de abril de 2025

Solicitar un pedido a granel

assay

>99% (TLC)

form

methylene chloride solution

packaging

pkg of 1 × 1 mL (700184M-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 700184M

concentration

1 mg/mL (700184M-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step.[1] It lacks a double bond between C24 and C25, which is present in cholesterol.[1] Desmosterol is the major brain sterol[2] and is localized in spermatozoa membrane and astrocytes.[1] Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.

Biochem/physiol Actions

Desmosterol is a liver X receptor (LXR) agonist[2] and it regulates inflammatory signaling in macrophages.[3] Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis.[1] It is a potential therapeutic target for treating the neurodegenerative disorder.[3]

Packaging

5 mL Clear Glass Sealed Ampule (700184M-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

wgk_germany

WGK 2

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Certificados de análisis (COA)

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Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in
Maurice Jansen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(3), 865-870 (2012-12-12)
The brain is the most cholesterol-enriched tissue in the body. During brain development, desmosterol, an immediate precursor of cholesterol, transiently accumulates up to 30% of total brain sterols. This massive desmosterol deposition appears to be present in all mammalian species
Phillip A Wages et al.
Journal of lipid research, 59(10), 1916-1926 (2018-08-09)
Regulating blood cholesterol (Chol) levels by pharmacotherapy has successfully improved cardiovascular health. There is growing interest in the role of Chol precursors in the treatment of diseases. One sterol precursor, desmosterol (Des), is a potential pharmacological target for inflammatory and

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