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Sigma-Aldrich

Methyllithium solution

1.6 M in diethyl ether

Sinónimos:

Lithium methanide, MeLi

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About This Item

Fórmula empírica (notación de Hill):
CH3Li
Número de CAS:
917-54-4
Peso molecular:
21.98
Beilstein/REAXYS Number:
3587162
MDL number:
MFCD00008253
UNSPSC Code:
12352103
PubChem Substance ID:
24851824
NACRES:
NA.22

vapor density

3 (vs air)

Quality Level

100

form

liquid

composition

halide, ~0.05 M

concentration

1.6 M in diethyl ether

density

0.732 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

[Li]C

InChI

1S/CH3.Li/h1H3;

InChI key

DVSDBMFJEQPWNO-UHFFFAOYSA-N

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General description

Methyllithium is an organolithium reagent mainly used for deprotonation and as a source of methyl anion. It is a strong base and a strong nucleophile.

Application

Methyllithium solution (1.6M in diethyl ether) has been used for the asymmetric allylic alkylation (AAA) of allylic electrophiles in the presence of a chiral copper catalyst. This protocol leads to the C-C bond formation of tertiary and quaternary stereogenic centers with high enantioselectivity. It can also be used for the synthesis of (−)-salsolidine by reacting with 6,7-dimethoxy-3,4-dihydroisoquinoline in the presence of (−)-sparteine as a chiral ligand.

Packaging

The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.
View returnable container options.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 2 - Pyr. Liq. 1 - Skin Corr. 1B - STOT SE 3 - Water-react 1

supp_hazards

EUH019,EUH066

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

wgk_germany

WGK 1

flash_point_f

1.4 °F - closed cup

flash_point_c

-17 °C - closed cup

Certificados de análisis (COA)

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We automated radiochemical synthesis of 1-[
Enantioselective addition of organolithium reagents to 3, 4-dihydroisoquinoline in the presence of (?)-sparteine as an external ligand. Application for the synthesis of isoquinoline alkaloids.
Chrzanowska M
Tetrahedron Asymmetry, 12(10), 1435-1440 (2001)
A Simplified Approach with 3D Visuals
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Essentials of Coordination Chemistry: A Simplified Approach with 3D Visuals, 183-183 (2015)
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Carbon monoxide (CO) has emerged as a potential therapeutic agent for the treatment of many diseases. However, the therapeutic outcome is highly dependent on the dosages and administration sites. Hence, there is mounting interest in the development of CO-releasing materials
Cu-catalyzed enantioselective allylic alkylation with organolithium reagents.
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