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191884

Sigma-Aldrich

Hydroxypropyl cellulose

average Mw ~100,000, powder, 20 mesh particle size (99% through)

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About This Item

Número de CAS:
9004-64-2
Número MDL:
MFCD00132688
Código UNSPSC:
12162002
NACRES:
NA.23

descripción

biological oxygen demand (BOD) 14,000 ppm

Nivel de calidad

200

Formulario

powder

temp. de autoignición

752 °F

mol peso

average Mw ~100,000

impurezas

<5 wt. %

tamaño de partícula

20 mesh (99% through)

pH

5.0-8.5

aceite mineral de tensión interfacial

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

viscosidad

65-175 cP, 5 wt. % in H2O(25 °C, Brookfield, spindle #1) (30 rpm)(lit.)

solubilidad

polar organic solvents: soluble

densidad

0.5 g/mL at 25 °C (lit.)

cadena SMILES

N(C)(C)c1cc(c(cc1)C(N)CC)C

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

Clave InChI

RRHXDYJWVYFMKV-UHFFFAOYSA-N

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Descripción general

Hydroxypropyl cellulose (HPC) is a neutral polysaccharide prepared by reacting propylene oxide with alkali cellulose at high temperatures and pressure. It is soluble in water and many polar organic solvents. HPC is widely used as a food additive and in drug delivery systems.

Aplicación

Hydroxypropyl cellulose can be used in the following applications:
  • HPC is soluble in organic solvents which makes it suitable for the preparation of polymer gel electrolytes for electrochemical devices. The network-forming ability of HPC can improve the mechanical and electrical properties of gel electrolytes.
  • Electrospun hydroxypropyl cellulose nanofibres can be used to develop drug delivery systems for a variety of hydrophobic drugs.
  • Hydroxypropylcellulose combined with an effervescent agent like sodium carbonate can be usedas a binder and functional material to prepare floating tablets for thecontrolled release of ofloxacin.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000373371
0000378591
0000373371
0000262190
0000346224

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Jeremiah F Kelleher et al.
AAPS PharmSciTech, 21(1), 23-23 (2019-12-14)
The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, correspondingly, the
Xiaole Qi et al.
International journal of pharmaceutics, 489(1-2), 210-217 (2015-05-10)
To prolong the residence time of dosage forms within gastrointestinal trace until all drug released at desired rate was one of the real challenges for oral controlled-release drug delivery system. Herein, we developed a fine floating tablet via compression coating
Daniela M Correia et al.
Materials (Basel, Switzerland), 13(10) (2020-05-21)
This study reports a versatile method for the development of cellulose nanocrystals (CNCs) and water-soluble cellulose derivatives (methyl cellulose (MC), hydroxypropyl cellulose (HPC), and sodium carboxymethyl cellulose (NaCMC)) films comprising the ionic liquid (IL) 2-hydroxy-ethyl-trimethylammonium dihydrogen phosphate ([Ch][DHP]) for actuator
Maya Fujiwara et al.
Chemical & pharmaceutical bulletin, 60(11), 1380-1386 (2012-11-06)
We evaluated models for predicting spray mist diameter suitable for scaling-up the fluidized bed granulation process. By precise selection of experimental conditions, we were able to identify a suitable prediction model that considers changes in binder solution, nozzle dimension, and
Ranjit M Dhenge et al.
International journal of pharmaceutics, 438(1-2), 20-32 (2012-09-11)
The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of
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