SML2811
Phenanthriplatin
>97% (NMR)
Synonym(s):
(SP-4-3)-Diamminechlorido(phenanthridine)platinum(II) nitrate, PhenPt, cis-[Pt(NH3)2(phenanthridine)Cl]NO3
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Check Cart for Availability | CLP 94,800 | |
| 25 mg | Check Cart for Availability | CLP 383,000 |
About This Item
Empirical Formula (Hill Notation):
C13H15ClN4O3Pt
CAS Number:
Molecular Weight:
505.81
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
>97% (NMR)
Form:
powder
Quality Segment
assay
>97% (NMR)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl[Pt](N)([N+]1=C2C=CC=CC2=C3C=CC=CC3=C1)N.[O-][N+]([O-])=O
InChI key
BELJCNWNXQVJPZ-UHFFFAOYSA-M
Biochem/physiol Actions
Cationic monofunctional DNA-binding platinum (II) complex with significantly greater anticancer activity than cisplatin, oxaliplatin, and pyriplatin.
Phenanthriplatin is a cationic monofunctional DNA-binding platinum (II) complex with significantly greater anticancer activity (IC50 in μM = 0.035/Ntera2, 0.22/A549, 0.30/HeLa, 0.59/U2OS, 0.74/PC3, 0.94/MCF7, 2.02/HT29; 72 h, MTT assay) than cisplatin, oxaliplatin, and pyriplatin. Enhanced cellular uptake due to its hydrophobic phenanthridine ligand as well as more rapid DNA covalent-binding activity both contribute to its superior anticancer efficacy. Phenanthriplatin binds more effectively to 5′-deoxyguanosine monophosphate than to N-acetyl methionine, whereas pyriplatin reacts equally to both.
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This Item | |||
|---|---|---|---|
| assay >97% (NMR) | assay >97% (NMR) | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 0.2 mg/mL (warmed) | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/mL, clear |
| color white to beige | color faint yellow to dark orange | color white to brown | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2811-5MG | 04061842182664 |
| SML2811-25MG | 04061842182657 |