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O0886

Olomoucine

≥98% (HPLC)

Synonym(s):

2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine

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1 mg
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CLP 73,000
5 mg
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CLP 224,000

About This Item

Empirical Formula (Hill Notation):
C15H18N6O
CAS Number:
101622-51-9
Molecular Weight:
298.34
NACRES:
NA.77
PubChem Substance ID:
24278053
UNSPSC Code:
12352200
MDL number:
MFCD00189360
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

CLP 73,000

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Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

DMSO: 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12

InChI

1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)

InChI key

GTVPOLSIJWJJNY-UHFFFAOYSA-N

Gene Information

human ... CDC2(983), CDK2(1017), CDK3(1018), CDK4(1019), CDK5(1020), CDK6(1021), CDK7(1022), CDK8(1024), CDK9(1025), CDKN1A(1026), CDKN1B(1027), CDKN1C(1028), CDKN2A(1029), CDKN2B(1030), CDKN2C(1031), CDKN2D(1032), CDKN3(1033)
rat ... Prkca(24680)

Biochem/physiol Actions

Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Olomoucine ≥98% (HPLC)

Sigma-Aldrich

O0886

Olomoucine

Ogerin ≥98% (HPLC)

Sigma-Aldrich

SML1482

Ogerin

Purmorphamine ≥98% (HPLC)

Sigma-Aldrich

SML0868

Purmorphamine

SMBA1 ≥98% (HPLC)

Sigma-Aldrich

SML1464

SMBA1

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 20 mg/mL, clear, colorless

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

Gene Information

human ... CDC2(983), CDK2(1017), CDK3(1018), CDK4(1019), CDK5(1020), CDK6(1021), CDK7(1022), CDK8(1024), CDK9(1025), CDKN1A(1026), CDKN1B(1027), CDKN1C(1028), CDKN2A(1029), CDKN2B(1030), CDKN2C(1031), CDKN2D(1032), CDKN3(1033)
rat ... Prkca(24680)

Gene Information

-

Gene Information

-

Gene Information

-

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCR9067
MKCV0158
MKCR1870
MKCS3267
MKBW6142V

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R T Abraham et al.
Biology of the cell, 83(2-3), 105-120 (1995-01-01)
Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. The unusual specificity of this compound towards cell
Brajendra K Tripathi et al.
Molecular vision, 14, 542-549 (2008-04-04)
To investigate the effect of the Cdk5 inhibitor olomoucine on corneal debridement wound healing in vivo. Corneal debridement wounds of 1.5 mm were made on the ocular surface of CD-1 mice. A 20 microl drop of 15 microM olomoucine in
J Veselý et al.
European journal of biochemistry, 224(2), 771-786 (1994-09-01)
While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine (olomoucine). Kinetic analysis of kinase inhibition reveals that olomoucine
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Global Trade Item Number

SKUGTIN
O0886-5MG04061834212676
O0886-1MG04061834212669

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