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C0984
Creatine Kinase MB Fraction from human heart
≥70% (SDS-PAGE), liquid
Synonym(s):
CK MB Fraction
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| Size/SKU | Availability | Price |
|---|---|---|
100 μg | Check Cart for Availability | CLP 409,000 |
About This Item
Assay:
≥70% (SDS-PAGE)
Biological source:
human heart
Concentration:
≥0.5 mg/mL
General description
Research area: Cell Signaling
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.
Application
Creatine Kinase MB Fraction from human heart has been used:
- as a diagnostic marker for acute myocardial infarction.[1]
- to identify overlapping absorbance peaks between blood and the cardiac biomarkers.
- to study the phosphorylation pathway of dioxolane guanosine (DXG) in vivo, a potential treatment of HIV-1 infection.
Biochem/physiol Actions
Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate. The enzyme is associated with coronary performance. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury. It is regarded as a “gold standard” for myocardial infarction diagnosis. The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels.[2] CK-MB levels may also be elevated in chronic renal failure.[3]
Other Notes
Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.
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This Item | |||
|---|---|---|---|
| biological source human heart | biological source - | biological source human heart | biological source human heart |
| assay ≥70% (SDS-PAGE) | assay - | assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| technique(s) IR spectroscopy: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable, mass spectrometry (MS): suitable, western blot (chemiluminescent): suitable | technique(s) - |
| Gene Information human ... CKB(1152), CKM(1158) | Gene Information human ... CKM(1158) | Gene Information human ... CYCS(54205), CYCSL1(157317) | Gene Information human ... MB(4151) |
| form liquid | form lyophilized powder | form lyophilized powder | form buffered aqueous glycerol solution |
| application(s) pharmaceutical | application(s) - | application(s) - | application(s) - |
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the Department of Transportation shipping information for this product?
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What does the MB stand for in Product C0984, Creatine Kinase MB Fraction from human heart?
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Creatine Kinase is a dimer that exists as three isozymes: MM (muscle), MB (hybrid) and BB (brain).
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