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47775

Supelco

Menadione (K3)

analytical standard

Sinonimo/i:

Menadione, 2-Methyl-1,4-naphthoquinone, Vitamin K3

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About This Item

Formula empirica (notazione di Hill):
C11H8O2
Numero CAS:
58-27-5
Peso molecolare:
172.18
Beilstein:
1908453
Numero CE:
200-372-6
Numero MDL:
MFCD00001681
Codice UNSPSC:
12164500
ID PubChem:
24871411

Grado

analytical standard

CdA

current certificate can be downloaded

Caratteristiche

standard type fat soluble vitamin

Confezionamento

ampule of 1000 mg

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

105-107 °C (lit.)

applicazioni

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

CC1=CC(=O)c2ccccc2C1=O

InChI

1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
MJVAVZPDRWSRRC-UHFFFAOYSA-N

Informazioni sul gene

human ... NQO1(1728)

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Categorie correlate

Descrizione generale

Menadione (K3) is a fat-soluble vitamin precursor and catabolic product of oral phylloquinone (vitamin k1) in the intestine.
Menadione is a prothrombogenic compound and belongs to the Vitamin K class of compounds, which are necessary for the biosynthesis of prothrombin and other blood clotting factors. It is used as a model quinone in cell culture and in vivo investigations. It is obtained as a catabolic product of phylloquinone and circulating precursor of tissue menaquinone-4 in rats.

Applicazioni

Menadione (K3) may be used as an analytical reference standard for the quantification of the analyte in biological fluids using liquid chromatography technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Exclamation markEnvironment
GHS07,GHS09

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H317,H319,H335,H410

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificati d'analisi (COA)

Lot/Batch Number
LRAD2358
LRAC4189
LRAC0446
LRAB6871
LC22078V

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Supelco

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Supelco

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Development of a validated liquid chromatography method for the simultaneous determination of eight fat-soluble vitamins in biological fluids after solid-phase extraction
Chatzimichalakis FP, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 805(2), 289-296 (2004)
F Jerry Reen et al.
PloS one, 8(1), e54479-e54479 (2013-02-06)
LysR-type transcriptional regulators (LTTRs) are emerging as key circuit components in regulating microbial stress responses and are implicated in modulating oxidative stress in the human opportunistic pathogen Pseudomonas aeruginosa. The oxidative stress response encapsulates several strategies to overcome the deleterious
Daiki Habu et al.
JAMA, 292(3), 358-361 (2004-07-22)
Previous findings indicate that vitamin K2 (menaquinone) may play a role in controlling cell growth. To determine whether vitamin K2 has preventive effects on the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. Forty women diagnosed
Kerry Routenberg Love et al.
Nature chemical biology, 3(11), 697-705 (2007-10-20)
The addition of ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers to proteins serves to modulate function and is a key step in protein degradation, epigenetic modification and intracellular localization. Deubiquitinating enzymes and Ubl-specific proteases, the proteins responsible for the removal of
H H Thijssen et al.
The British journal of nutrition, 75(1), 121-127 (1996-01-01)
We measured the vitamin K status in postmortem human tissues (brain, heart, kidney, liver, lung, pancreas) to see if there is a tissue-specific distribution pattern. Phylloquinone (K1) was recovered in all tissues with relatively high levels in liver, heart and
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Protocolli

HPLC Analysis of Fat Soluble Vitamins by Normal Phase Chromatography on Ascentis® Si

Separation of (±)-α-Tocopherol, analytical standard; Menadione (K3), analytical standard; (+)-γ-Tocopherol, analytical standard; Cholecalciferol (D3), analytical standard

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