Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

W1520

Sigma-Aldrich

WAY-200070

≥98% (HPLC)

Sinonimo/i:

7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol, 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C13H8BrNO3
Numero CAS:
440122-66-7
Peso molecolare:
306.11
Numero MDL:
MFCD16618385
Codice UNSPSC:
51111800
ID PubChem:
329830426
NACRES:
NA.77
Prezzi e disponibilità al momento non sono disponibili

Saggio

≥98% (HPLC)

Stato

solid

Solubilità

DMSO: ≥20 mg/mL

Ideatore

Wyeth

Temperatura di conservazione

2-8°C

Stringa SMILE

Oc1ccc(cc1)-c2nc3cc(O)cc(Br)c3o2

InChI

1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H
BAAILVWEAXFTSF-UHFFFAOYSA-N

Descrizione generale

WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Applicazioni

WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response.[1][2] WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.[3]

Azioni biochim/fisiol

Potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Caratteristiche e vantaggi

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H319

Classi di pericolo

Acute Tox. 3 Oral - Eye Irrit. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
0000418300
0000418300
050M4622V

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Amy E Clipperton-Allen et al.
Psychoneuroendocrinology, 36(7), 981-995 (2011-01-21)
Gonadal hormones mediate both affiliative and agonistic social interactions. Research in estrogen receptor alpha (ERα) or beta (ERβ) knockout (KO) mice suggests that ERα increases and ERβ decreases male aggression, while the opposite is found for female ERαKO and ERβKO
Paloma Alonso-Magdalena et al.
Diabetes, 62(6), 2015-2025 (2013-01-26)
The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances
Claus Lattrich et al.
Archives of gynecology and obstetrics, 289(1), 163-171 (2013-08-03)
Coexpression of estrogen receptors (ER) α and β is present in about half of all breast cancer cases. Whereas ERα is a well-established target for endocrine therapy with the selective estrogen receptor modulator tamoxifen, the applicability of ERβ as target
Lidia I Serova et al.
The Journal of endocrinology, 205(3), 253-262 (2010-03-30)
Previously, pretreatment with estradiol benzoate (EB) was found to modulate the response of hypothalamic-pituitary-adrenal (HPA) axis and gene expression in several catecholaminergic neuronal locations in ovariectomized (OVX) rats exposed to single immobilization stress (IMO). Here, we investigated the role of
Matthew D Hale et al.
Biology of reproduction, 100(1), 149-161 (2018-07-17)
Estrogens regulate key aspects of sexual determination and differentiation, and exposure to exogenous estrogens can alter ovarian development. Alligators inhabiting Lake Apopka, FL, are historically exposed to estrogenic endocrine disrupting contaminants and are characterized by a suite of reproductive abnormalities
Visualizza tutti i documenti correlati

Questions

Reviews

No rating value

Active Filters

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.