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V4877

Sigma-Aldrich

Verrucarin A from Myrothecium sp.

≥85.0% (HPLC)

Sinonimo/i:

Muconomycin A

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1 MG
CHF 221.00
5 MG
CHF 438.00

CHF 221.00

Spedizione prevista il14 aprile 2025

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1 MG
CHF 221.00
5 MG
CHF 438.00

About This Item

Formula empirica (notazione di Hill):
C27H34O9
Numero CAS:
3148-09-2
Peso molecolare:
502.55
Numero MDL:
MFCD00056759
Codice UNSPSC:
12352200
ID PubChem:
24900750
NACRES:
NA.77

CHF 221.00

Spedizione prevista il14 aprile 2025

Richiedi un ordine bulk

Livello qualitativo

200

Saggio

≥85.0% (HPLC)

Temperatura di conservazione

−20°C

Stringa SMILE

CC1CCOC(=O)\C=C\C=C\C(=O)OC2CC3OC4C=C(C)CCC4(COC(=O)C1O)C2(C)C35CO5

InChI

1S/C27H34O9/c1-16-8-10-26-14-33-24(31)23(30)17(2)9-11-32-21(28)6-4-5-7-22(29)36-18-13-20(35-19(26)12-16)27(15-34-27)25(18,26)3/h4-7,12,17-20,23,30H,8-11,13-15H2,1-3H3/b6-4+,7-5+
NLUGUZJQJYVUHS-YDFGWWAZSA-N

Descrizione generale

Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen[1] is a macrocyclic trichothecene compound.[2]

Applicazioni

Verrucarin A from Myrothecium sp has been used:
  • as a translation initiation inhibitor in P. falciparum W2 strain[3]
  • as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells[4]
  • to test its cytotoxicity in renal cell carcinoma cells[1]

Azioni biochim/fisiol

Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation.[3] It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation.[1] Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells[2]
Verrucarin A is phytotoxic to plantlet cultures and cytotoxic to cultured mammalian cell lines.

Altre note

Macrocyclic trichothecene mycotoxin.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330

Classi di pericolo

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000373975
0000373975
0000224898
0000180270
0000180269

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SB 216763 >98% (HPLC)

Sigma-Aldrich

S3442

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Cycloheximide ≥90% (HPLC)

Sigma-Aldrich

01810

Cycloheximide

Antonio L Amelio et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(51), 20314-20319 (2007-12-14)
Signal transduction pathways often use a transcriptional component to mediate adaptive cellular responses. Coactivator proteins function prominently in these pathways as the conduit to the basic transcriptional machinery. Here we present a high-throughput cell-based screening strategy, termed the "coactivator trap,"
Charles S Bond et al.
The Journal of cell biology, 186(5), 637-644 (2009-09-02)
Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and
Maria C Dzialo et al.
The Journal of biological chemistry, 289(44), 30511-30524 (2014-09-19)
Methylation of various components of the translational machinery has been shown to globally affect protein synthesis. Little is currently known about the role of lysine methylation on elongation factors. Here we show that in Saccharomyces cerevisiae, the product of the
Dorrah Deeb et al.
International journal of oncology, 49(3), 1139-1147 (2016-08-31)
Pancreatic ductal adenocarcinoma (PDA) remains one of the most difficult to treat of all malignancies. Multimodality regimens provide only short-term symptomatic improvement with minor impact on survival, underscoring the urgent need for novel therapeutics and treatment strategies for PDA. Trichothecenes
Chien-Shan Cheng et al.
Cancer cell international, 19, 92-92 (2019-04-24)
In the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its main active constituent Bufalin have been studied in vitro, in vivo and clinical studies. This review aims to
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