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T6514

Sigma-Aldrich

Oleandomycin triacetate

Sinonimo/i:

Troleandomycin

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About This Item

Formula empirica (notazione di Hill):
C41H67NO15
Numero CAS:
2751-09-9
Peso molecolare:
813.97
Beilstein:
1418238
Numero CE:
220-392-9
Numero MDL:
MFCD00871198
Codice UNSPSC:
51101500

Modalità d’azione

enzyme | inhibits
protein synthesis | interferes

Stringa SMILE

CO[C@H]1C[C@@H](O[C@@H](C)[C@@H]1OC(C)=O)O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(C)=O)N(C)C)[C@@H](C)C[C@@]4(CO4)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C

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Descrizione generale

Chemical structure: macrolide

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Soo H Bae et al.
The Journal of pharmacy and pharmacology, 61(12), 1637-1642 (2009-12-05)
It has been reported that hepatic cytochrome P450 (CYP)2C9 and CYP3A4 are responsible for the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in humans. However, in-vivo studies in rats have not been reported. Sildenafil (20 mg/kg) was administered
Güliz Gürel et al.
Antimicrobial agents and chemotherapy, 53(12), 5010-5014 (2009-09-10)
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the
Shobana Ganesan et al.
Toxicology and applied pharmacology, 241(1), 14-22 (2009-07-21)
Primaquine, an 8-aminoquinoline, is the drug of choice for radical cure of relapsing malaria. Use of primaquine is limited due to its hemotoxicity, particularly in populations with glucose-6-phosphate dehydrogenase deficiency [G6PD(-)]. Biotransformation appears to be central to the anti-infective and
Daniel R Albaugh et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(7), 1336-1344 (2012-04-12)
The current studies assessed the utility of freshly plated hepatocytes, cryopreserved plated hepatocytes, and cryopreserved plated HepaRG cells for the estimation of inactivation parameters k(inact) and K(I) for CYP3A. This was achieved using a subset of CYP3A time-dependent inhibitors (fluoxetine
E Y Oh et al.
British journal of pharmacology, 151(1), 24-34 (2007-03-14)
Recently, orthostatic hypotension was observed in patients with benign prostatic hyperplasia who are taking vardenafil (a PDE 5 inhibitor) and terazosin (a long acting alpha blocker). Therefore, this study was performed with DA-8159 (a long acting PDE 5 inhibitor) and
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