T2879

Tyramine hydrochloride

≥98% (TLC), powder, neuromodulator

• Sinonimo/i: 4-(2-Aminoethyl)phenol hydrochloride, 4-Hydroxyphenethylamine hydrochloride, Tyrosamine hydrochloride
• Formula condensata: HOC₆H₄CH₂CH₂NH₂ · HCl
• Numero CAS: 60-19-5
• Peso molecolare: 173.64
• Beilstein: 3627058
• Numero CE: 200-462-5
• Numero MDL: MFCD00012901
• Codice UNSPSC: 12352116
• ID PubChem: 24277896
• NACRES: NA.77

Proprietà

• Nome del prodotto: Tyramine hydrochloride, ≥98%
• Livello qualitativo: 200
• Saggio: ≥98%
• Punto di fusione: 271-274 °C (lit.)
• Solubilità: H₂O: soluble 50 mg/ml, clear, colorless to faintly yellow
• Stringa SMILE: Cl[H].NCCc1ccc(O)cc1
• InChI: 1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H; RNISDHSYKZAWOK-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADORA2A(135) , ADORA2B(136) , ADORA3(140)

Descrizione

Applicazioni

Tyramine hydrochloride has been:

• coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure[1]
• labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis[2]
• used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification[3]

Azioni biochim/fisiol

Tyramine is a biogenic amine and a neuromodulator[4] localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders.[5] Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content.[6]

Can enter catecholaminergic terminals and be released as a false transmitter.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves